Synthesis of New 3,5-disubstituted-1,2,4-Triazoles and Evaluation of Antibacterial, Antiurease and Antioxidant Activities
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chem Soc Pakistan
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Acylhydrazone 2 was synthesized by the condensation of iminoester hydrochloride 1 with acyl hydrazine. The treatment of acylhydrazone with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4-triazole 3. The treatment of compound 3 with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3, 5-dialkyl-1,2,4-triazoles 4a-c. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3,5-dialkyl- 1,2,4-triazoles 5a-c. The obtained products were identified by FTIR, H-1-NMR, C-13-NMR, Mass spectroscopic and elemental analysis. A series of compounds were evaluated for their, antibacterial, antiurease, antioxidant activities. The results showed that the synthesized new compounds had effective antibacterial, antioxidant, antiurease activities.
Açıklama
Sahin, Huseyin/0000-0002-6018-1494
WOS: 000390364000016
WOS: 000390364000016
Anahtar Kelimeler
1,2,4-triazole, Schiff base, Reduction, Urease inhibition activity, Antioxidant activity
Kaynak
Journal Of The Chemical Society Of Pakistan
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
38
Sayı
5
