Effect of consuming high-fat diet on the morphological parameters of adrenal gland

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dc.contributor.authorTopal, F.
dc.contributor.authorGören, Hilal
dc.contributor.authorYücel, F.
dc.contributor.authorŞahintürk, V.
dc.contributor.authorAydar, Y.
dc.date.accessioned2020-05-01T09:11:37Z
dc.date.available2020-05-01T09:11:37Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionTOPAL, Fatma/0000-0003-3491-4970; Sahinturk, Varol/0000-0003-2317-3644; AYDAR, Yuksel/0000-0002-0285-9914en_US
dc.descriptionWOS: 000482675200010en_US
dc.descriptionPubMed: 31379183en_US
dc.description.abstractOBJECTIVES: The incidence of obesity and obesity-assosiated pathologies continues to increase with profound adverse effects on health status in the developed countries. BACKGROUND: We aimed to investigate the effect of high fat diet on the adrenal gland morphology. METHODS: We fed the mice with either high-fat diet (60 % kcal from fat) or low-fat diet (10 % kcal from fat) for nine weeks. Unbiased stereological methods were used to evaluate the adrenal gland morphology. The sections were evaluated using Cavalieri's method and volume fraction approach. We calculated mean volume of adrenal gland, mean volume of adrenal medulla, V-Vadrenal (medulla/adrenal gland,) mean diameter of cromaffin cells, number of chromaffin cells in per unit volume (N-Vcc mm(-3)), total number of cromaffin cells, V-Vzona (glomerulosa/adrenal cortex,) V-Vzona (fasciculata/adrenal) (cortex,) V-Vzona (reticulosa/adrenal cortex.) RESULTS: The weight of adrenal gland, body weight intraperitoneal adipose tissue and adrenal gland weight in the obese mice significantly increased when compared with the control group. No changes were observed in the mean volume of adrenal gland, mean volume of adrenal medulla, V-Vzona (glomerulosa/adrenal cortex,) V-Vzona fasciculata/adrenal cortex,V- total number of cromaffin cells and diameter of cromaffin cells. However, N-Vcc mm(-3) and V-Vzona (reticulosa/adrenal cortex) in the obese mice considerably increased compared with the control group. CONCLUSION: The present results suggest that high fat diet adversely affects the adrenal gland morphology.en_US
dc.description.sponsorshipEskisehir Osmangazi University Research Projects Center [2014-586]en_US
dc.description.sponsorshipThe present study was also financially supported by Eskisehir Osmangazi University Research Projects Center with the project code 2014-586.en_US
dc.identifier.doi10.4149/BLL_2019_097en_US
dc.identifier.endpage600en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2019_097
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5689
dc.identifier.volume120en_US
dc.identifier.wosWOS:000482675200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthigh-fat dieten_US
dc.subjectmorphologyen_US
dc.subjectobesityen_US
dc.subjectadrenal glanden_US
dc.subjectstereologyen_US
dc.titleEffect of consuming high-fat diet on the morphological parameters of adrenal glanden_US
dc.typeArticleen_US

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