Continuous 900-megahertz electromagnetic field applied in middle and late-adolescence causes qualitative and quantitative changes in the ovarian morphology, tissue and blood biochemistry of the rat

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dc.contributor.authorOkatan, Derya Öztürk
dc.contributor.authorKaya, Haydar
dc.contributor.authorAliyazıcıoğlu, Yüksel
dc.contributor.authorDemir, Selim
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorOdacı, Ersan
dc.date.accessioned2020-04-30T22:41:40Z
dc.date.available2020-04-30T22:41:40Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionDemir, Selim/0000-0002-1863-6280en_US
dc.descriptionWOS: 000427080600010en_US
dc.descriptionPubMed: 29268055en_US
dc.description.abstractPurpose: The purpose of this study was to use histological and biochemical methods in order to evaluate changes taking place in the ovarian of rats exposed to the effect of a 900-megahertz (MHz) electromagnetic field (EMF) in middle and late adolescence. Materials and methods: Twenty-four 34-d-old female Sprague-Dawley rats were assigned equally to control, sham and EMF groups. EMF group rats were exposed to the effect of a 900-MHz EMF for 1 h a day, at the same time every day between postnatal days 35 and 59, while inside an EMF cage. Sham group rats were kept inside the EMF cage for the same time between postnatal days 35 and 59 without being exposed to any EMF effect. At the end of the study, rats' ovarian were removed and blood specimens were taken. Right ovarium tissues were subjected to routine histological procedures and stained with hematoxylin and eosin, periodic acid shift and Masson's trichrome. Follicles were counted in ovarian sections stained with hematoxylin and eosin. The TUNEL method was used to evaluate apoptosis. Left ovarian tissue and blood specimens were investigated biochemically. Results: Histopathological examination of EMF group ovarian tissue revealed thinning in the zona granulosa and theca layers, shrinking in granulosa cells, reduced mitotic activity and leukocyte infiltration in the follicles and stroma. Secondary follicle numbers in the EMF group were significantly lower than in the other groups. In terms of biochemistry, EMF and sham group superoxide dismutase, catalase and anti-Mullerian hormone levels and EMF group 3-nitrotyrosine values increased significantly compared to the control group. EMF and sham group serum catalase and 8-hydroxy-deoxiguanosine values increased significantly compared to the control group, and EMF group total oxidant status and oxidative stress index values were significantly higher compared to the sham and control groups. Conclusions: A total of 900-MHz EMF applied in middle and late adolescence may cause changes in the morphology and biochemistry of the rat ovarium.en_US
dc.description.sponsorshipKaradeniz Technical University Research Fund [TTU-2015-5240]en_US
dc.description.sponsorshipThis research was supported by the Karadeniz Technical University Research Fund, Project number TTU-2015-5240.en_US
dc.identifier.doi10.1080/09553002.2018.1420924en_US
dc.identifier.endpage198en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.1080/09553002.2018.1420924
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3229
dc.identifier.volume94en_US
dc.identifier.wosWOS:000427080600010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Radiation Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectromagnetic fielden_US
dc.subjectmiddle and late adolescenceen_US
dc.subjectovariumen_US
dc.subjectraten_US
dc.titleContinuous 900-megahertz electromagnetic field applied in middle and late-adolescence causes qualitative and quantitative changes in the ovarian morphology, tissue and blood biochemistry of the raten_US
dc.typeArticleen_US

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