The Histopathological Findings of Adenoid Tissue After Topical Mometasone Furoate Implementation

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dc.contributor.authorAkcan, Fatih Alper
dc.contributor.authorAkcan, Hümeyra Bayram
dc.contributor.authorDündar, Yusuf
dc.contributor.authorUluat, Ahmet
dc.contributor.authorKarakuş, Esra
dc.date.accessioned2020-04-30T23:33:45Z
dc.date.available2020-04-30T23:33:45Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000441304600013en_US
dc.description.abstractObjective: Pediatric sleep disordered breathing (SDB) is a common childhood disease with a potential risk of several comorbidities. The most common cause of SDB in childhood is upper airway obstruction due to adenotonsillar hypertrophy and the classical treatment is adenotonsillectomy. However, it carries a risk of many complications and persistent apnea. Topical nasal steroid treatment may be an alternative to surgery in the treatment of pediatric SDB. However, histopathological effects of topical nasal steroids are mostly understudied. Methods: A retrospective controlled clinical study in an academic tertiary referral center. A total of 110 children were involved in the study who underwent adenoidectomy for the treatment of SDB. The study group (51-children) was treated with topical nasal mometasone furoate monohydrate 100 mcg/day. The control group (59-children) was selected randomly and all had no history of topical nasal steroid pre-operatively. Post-operative adenoidectomy specimens were reviewed according to acute/chronic inflammation findings, follicular hyperplasia, goblet cell hyperplasia, squamous metaplasia, fibrosis, atrophy, ulcer and hemorrhage. The findings were scored semiquantitatively for statistical analysis. Results: Chronic inflammation findings, follicular hyperplasia and goblet cell hyperplasia were significantly decreased in the study group in addition fibrosis, atrophy and ulcer findings were significantly increased in the study group. However, there was no statistical difference between the groups according to acute inflammation and hemorrhage. Conclusions: Topical nasal corticosteroids significantly suppress the nasopharyngeal inflammatory process in SDB. This treatment may be an alternative to surgery at least in patients with mild and moderate disease.en_US
dc.identifier.doi10.18521/ktd.365710en_US
dc.identifier.endpage207en_US
dc.identifier.issn1309-3878
dc.identifier.issue2en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.365710
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5036
dc.identifier.volume10en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univen_US
dc.relation.ispartofKonuralp Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSleep Disordered Breathingen_US
dc.subjectAdenotonsillectomyen_US
dc.subjectNasal Corticosteroiden_US
dc.subjectHistopathologyen_US
dc.titleThe Histopathological Findings of Adenoid Tissue After Topical Mometasone Furoate Implementationen_US
dc.typeArticleen_US

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