Neuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury

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dc.contributor.authorNazlı, Yunus
dc.contributor.authorÇolak, Necmettin
dc.contributor.authorAlpay, Mehmet Fatih
dc.contributor.authorUysal, Sema
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorÇakır, Omer
dc.date.accessioned2020-04-30T23:19:30Z
dc.date.available2020-04-30T23:19:30Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000349619500010en_US
dc.descriptionPubMed: 25672430en_US
dc.description.abstractOBJECTIVES: Prevention of the development of paraplegia during the repair of the damage caused by descending thoracic and thoracoabdominal aneurysms remains an important issue. Therefore, we investigated the protective effect of atorvastatin on ischemia-induced spinal cord injury in a rabbit model. METHOD: Thirty-two rabbits were divided into the following four equally sized groups: group I (control), group II (ischemia-reperfusion), group III (atorvastatin treatment) and group IV (atorvastatin withdrawal). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the iliac bifurcation. Seventy-two hours postoperatively, the motor function of the lower limbs of each animal was evaluated according to the Tarlov score. Spinal cord and blood samples were obtained for histopathological and biochemical analyses. RESULTS: All of the rabbits in group II exhibited severe neurological deficits. Atorvastatin treatment (groups III and IV) significantly reduced the level of motor dysfunction. No significant differences were observed between the motor function scores of groups III and IV at the evaluated time points. Light microscopic examination of spinal cord tissue samples obtained at the 72nd hour of reperfusion indicated greater tissue preservation in groups III and IV than in group II. CONCLUSION: This study demonstrates the considerable neuroprotective effect of atorvastatin on the neurological, biochemical and histopathological status of rabbits with ischemia-induced spinal cord injury. Moreover, the acute withdrawal of atorvastatin therapy following the induction of spinal cord ischemia did not increase the neuronal damage in this rabbit model.en_US
dc.identifier.doi10.6061/clinics/2015(01)10en_US
dc.identifier.endpage60en_US
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.6061/clinics/2015(01)10
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3774
dc.identifier.volume70en_US
dc.identifier.wosWOS:000349619500010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHospital Clinicas, Univ Sao Pauloen_US
dc.relation.ispartofClinicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtorvastatinen_US
dc.subjectSpinal Corden_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.titleNeuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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