Correlation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinoma

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dc.contributor.authorErdem, Havva
dc.contributor.authorGündoğdu, Cemal
dc.contributor.authorŞipal, Sare
dc.date.accessioned2020-04-30T22:41:49Z
dc.date.available2020-04-30T22:41:49Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionGundogdu, Cemal/0000-0003-2857-923Xen_US
dc.descriptionWOS: 000290839100012en_US
dc.descriptionPubMed: 21335003en_US
dc.description.abstractThyroid cancer represents approximately 1% of all human malignancies, papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, accounting for 70-80% of all thyroid cancers. In the US, the incidence of thyroid cancer is 4 per 100,000 individuals. It is two to four times as frequent in women as in men. The development of PTC is influenced by many factors including genetic alterations, growth factors, and physical agents such as radiation. In order to recognize the prognosis for PTC. a lot of clinic and pathological parameters such as: age, tumor size, extra-thyroid tumor spread, lymph node, distant metastases, gender, tumor stage are used. As most of these parameters are subjective, more objective and useful prognostic factors are needed for determining biologic behavior, providing an initial assessment. In this study, we aimed to compare the expressions of COX-2, E-cadherin, VEGF to classical prognostic factors, and to investigate the correlation with prognosis. Operation records from 79 FTC cases were examined retrospectively. In the study, we aimed to investigate the whole tissue by means of stereology method, which is an impartial one, and we indicated the expression COX-2, VEGF, E-cadherin immunohistochemically in 79 resection diagnosed with PTC. We determined correlations between the expressions of COX-2 and VEGF, E-cadherin, and age, gender, and stage. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.yexmp.2011.01.008en_US
dc.identifier.endpage317en_US
dc.identifier.issn0014-4800
dc.identifier.issn1096-0945
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org/10.1016/j.yexmp.2011.01.008
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3253
dc.identifier.volume90en_US
dc.identifier.wosWOS:000290839100012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofExperimental And Molecular Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPTCen_US
dc.subjectCOX-2en_US
dc.subjectVEGFen_US
dc.subjectE-cadherinen_US
dc.subjectPrognostic factorsen_US
dc.titleCorrelation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinomaen_US
dc.typeArticleen_US

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