Gender Specificity of Genistein Treatment in Penicillin-Induced Epileptiform Activity in Rats

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dc.contributor.authorBahadır, Anzel
dc.contributor.authorDemir, Şerif
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-05-01T12:10:09Z
dc.date.available2020-05-01T12:10:09Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionOrallar, Hayriye/0000-0002-0000-3768; CETINKAYA, Ayhan/0000-0002-8212-7149; Ankarali, Handan Camdeviren/0000-0002-3613-0523; ankarali, seyit/0000-0003-3752-0846en_US
dc.descriptionWOS: 000398197300006en_US
dc.description.abstractWe investigated gender-dependent differences of genistein (isoflavone phytoestrogen) treatment in a penicillin-induced experimental epilepsy rat model. Twenty-eight adult Wistar Albino rats (14 females and 14 males) were devided into four groups, control and genistein-treatmed males and females. Genistein (100 mu g/kg, i.p) or saline was given during 15 days before the electrocorticography (ECoG) recordings. The epileptiform activity was induced by penicillin G potassium salt (500 IU) injections into the left somatomotor cortex. Significant differences among the groups were found in the latency to onset of epileptiform activity. This value in the female control group was significantly longer than the latencies in the male control, male genistein, and female genistein groups (respectively, P = 0.002, 0.015, and 0.032). There were no significant differences regarding the spike/wave frequencies and amplitudes in epileptiform activity between female/male genistein and control groups within all observation intervals (P > 0.05). Thus, genistein exerts a proconvulsant effect in the penicillin-induced epilepsy model, and the effect demonstrates the clear gender specificity related to the specificity of hormonal backgrounds in males and females.en_US
dc.identifier.doi10.1007/s11062-017-9619-9en_US
dc.identifier.endpage428en_US
dc.identifier.issn0090-2977
dc.identifier.issn1573-9007
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage421en_US
dc.identifier.urihttps://doi.org/10.1007/s11062-017-9619-9
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6045
dc.identifier.volume48en_US
dc.identifier.wosWOS:000398197300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgenisteinen_US
dc.subjectepileptiform activityen_US
dc.subjectelectrocorticography (ECoG)en_US
dc.subjectpenicillinen_US
dc.subjectraten_US
dc.titleGender Specificity of Genistein Treatment in Penicillin-Induced Epileptiform Activity in Ratsen_US
dc.typeArticleen_US

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