Gender Specificity of Genistein Treatment in Penicillin-Induced Epileptiform Activity in Rats
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
We investigated gender-dependent differences of genistein (isoflavone phytoestrogen) treatment in a penicillin-induced experimental epilepsy rat model. Twenty-eight adult Wistar Albino rats (14 females and 14 males) were devided into four groups, control and genistein-treatmed males and females. Genistein (100 mu g/kg, i.p) or saline was given during 15 days before the electrocorticography (ECoG) recordings. The epileptiform activity was induced by penicillin G potassium salt (500 IU) injections into the left somatomotor cortex. Significant differences among the groups were found in the latency to onset of epileptiform activity. This value in the female control group was significantly longer than the latencies in the male control, male genistein, and female genistein groups (respectively, P = 0.002, 0.015, and 0.032). There were no significant differences regarding the spike/wave frequencies and amplitudes in epileptiform activity between female/male genistein and control groups within all observation intervals (P > 0.05). Thus, genistein exerts a proconvulsant effect in the penicillin-induced epilepsy model, and the effect demonstrates the clear gender specificity related to the specificity of hormonal backgrounds in males and females.
Description
Orallar, Hayriye/0000-0002-0000-3768; CETINKAYA, Ayhan/0000-0002-8212-7149; Ankarali, Handan Camdeviren/0000-0002-3613-0523; ankarali, seyit/0000-0003-3752-0846
WOS: 000398197300006
WOS: 000398197300006
Keywords
genistein, epileptiform activity, electrocorticography (ECoG), penicillin, rat
Journal or Series
Neurophysiology
WoS Q Value
Q4
Scopus Q Value
Q4
Volume
48
Issue
6
