Tranexamic Acid and Hyaluronate/Carboxymethylcellulose Create Cell Injury

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dc.contributor.authorYıldız, Elif
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorDilbaz, Serdar
dc.contributor.authorÜstün, Yusuf
dc.contributor.authorKumru, Selahattin
dc.date.accessioned2020-04-30T23:34:59Z
dc.date.available2020-04-30T23:34:59Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKUMRU, Selahattin/0000-0001-6615-7666;en_US
dc.descriptionWOS: 000348437400012en_US
dc.descriptionPubMed: 25392658en_US
dc.description.abstractBackground and Objectives: Postoperative pelvic adhesions are associated with chronic pelvic pain, dyspareunia, and infertility. The aim of this study was to evaluate the adhesion prevention effects of tranexamic acid (TA) and hyaluronate/carboxymethylcellulose (HA/CMC) barrier in the rat uterine horn models on the basis of macroscopic and microscopic adhesion scores and histopathological as well as biochemical parameters of inflammation. Methods: Twenty-one Wistar rats were randomly divided into 3 groups. Ten lesions were created on the antimesenteric surface of both uterine horns by bipolar cautery. Three milliliters of 0.9% sodium chloride solution were administered in the control group. A single layer of 2 x 2 cm HA/CMC was plated in group 2. Two milliliters of TA was applied in the last group. All rats were sacrificed at postoperative day 21. Results: No significant difference was found among the control group, the HA/CMC group, and the TA group in terms of macro-adhesion score (P = .206) and microadhesion score (P = .056). No significant difference was found among the 3 groups in terms of inflammation score (P = .815) and inflammatory cell activity (P = .835). Malondialdehyde levels were significantly lower in the control group than in the TA group and HA/CMC group (P = .028). Superoxide dismutase and glutathione S-transferase activities were found to be higher in the control group than in the TA group (P = .005) and HA/CMC group (P = .009). Conclusions: TA and HA/CMC had no efficacy in preventing macroscopic or microscopic adhesion formation and decreasing inflammatory cell activity or inflammation score in our rat models. TA and HA/CMC increased the levels of free radicals and reduced the activities of superoxide dismutase and glutathione S-transferase enzymes, which act to reduce tissue injury.en_US
dc.identifier.doi10.4293/JSLS.2014.00044en_US
dc.identifier.issn1086-8089
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.4293/JSLS.2014.00044
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5254
dc.identifier.volume18en_US
dc.identifier.wosWOS:000348437400012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Laparoendoscopic Surgeonsen_US
dc.relation.ispartofJsls-Journal Of The Society Of Laparoendoscopic Surgeonsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdhesionen_US
dc.subjectHyaluronate/carboxymethylcelluloseen_US
dc.subjectRaten_US
dc.subjectTranexamic aciden_US
dc.subjectUterine hornen_US
dc.titleTranexamic Acid and Hyaluronate/Carboxymethylcellulose Create Cell Injuryen_US
dc.typeArticleen_US

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