Increased adhesion formation after gelatin-thrombin matrix application in a rat model

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dc.contributor.authorÇağlar, Mete
dc.contributor.authorYavuzcan, Ali
dc.contributor.authorYıldız, Elif
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorDilbaz, Serdar
dc.contributor.authorKumru, Selahattin
dc.date.accessioned2020-04-30T23:18:28Z
dc.date.available2020-04-30T23:18:28Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKUMRU, Selahattin/0000-0001-6615-7666en_US
dc.descriptionWOS: 000340518300019en_US
dc.descriptionPubMed: 24748282en_US
dc.description.abstractTo evaluate the effects of gelatin matrix and thrombin-based hemostatic sealant agents (gelatin-thrombin matrix) on postoperative adhesion formation in the rat uterine horn model. A total of fourteen female Wistar-Albino rats were used in our postoperative adhesion formation model. Both uterine horns were exposed by midline incision with sterile technique and each uterine horn was traumatized by bipolar electrocautery. Before closure of the abdomen, 0.9 % NaCl solution was administered intraperitoneally in the control group and the gelatin-thrombin matrix was applied on the traumatized areas on the uterine horns of the rats in the study group. At day 21 after the first surgery, the intraperitoneal macroscopic adhesion scores and the extent of fibrosis, inflammation scores, inflammatory cell activities, inflammation types of adhesion tissues, and the level of free oxygen radicals [malondialdehyde (MDA)] and antioxidant enzyme activity [superoxide dismutase (SOD) and glutathione S-transferase (GST)] in the uterine horn tissue were measured. There was no statistically significant difference between the two groups in terms of macroscopic adhesion scores (p = 0.064), MDA levels (p = 0.121), and GST activity (p = 0.360). However, there was statistically significant difference between the two groups in terms of the extent of fibrosis (p < 0.001), inflammation score (p = 0.001), inflammatory cell activity (p = 0.002), and SOD activity (p < 0.001). Gelatin-thrombin matrix was found to have increased the extent of fibrosis, inflammatory cell activity, and inflammation score, and reduced the activity of SOD, which acts to prevent cell damage.en_US
dc.identifier.doi10.1007/s00404-014-3249-xen_US
dc.identifier.endpage506en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage501en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-014-3249-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3341
dc.identifier.volume290en_US
dc.identifier.wosWOS:000340518300019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesionen_US
dc.subjectGelatin-thrombin matrixen_US
dc.subjectInflammationen_US
dc.subjectRaten_US
dc.titleIncreased adhesion formation after gelatin-thrombin matrix application in a rat modelen_US
dc.typeArticleen_US

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