Effect of ATP-dependent channel modulators on ischemia-induced arrhythmia change depending on age and gender

Basit Öğe Kaydı
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorYaşar, Selçuk
dc.contributor.authorOrallar, Hayriye
dc.date.accessioned2020-05-01T09:11:36Z
dc.date.available2020-05-01T09:11:36Z
dc.date.issued2013
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.descriptionOrallar, Hayriye/0000-0002-0000-3768; YASAR, Selcuk/0000-0002-9677-8823; YASAR, SELCUK/0000-0002-9677-8823; Yasar, Selcuk/0000-0002-7529-9751en_US
dc.descriptionWOS: 000324914200009en_US
dc.descriptionPubMed: 24000380en_US
dc.description.abstractThe number of ATP-dependent potassium channels in myocardial cells has been previously shown to change depending on gender and age. Different effects of the ATP-dependent potassium channel blocker, glybenclamide and ATP-dependent potassium channel opener, pinacidil on ischemia or reperfusion-induced arrhythmia observed in various research might depend on different ages and genders of the animals used. The aim of this study is to research the effect of ATP-dependent potassium channel modulators on ischemia-induced arrhythmia in animals of different ages and genders. Sprague-Dawley rats of different ages and genders were used in this study. Ischemia was produced by the ligation of the left coronary artery for 30 min. Electrocardiogram (ECG), blood pressure, infarct area and blood glucose were determined during the 30 min of ischemia. An arrhythmia score from an ECG recorded during 30 min of ischemia was determined by examining the duration and type of arrhythmia. Different effects of glybenclamide and pinacidil on the arrhythmias were observed in male and female young and middle-age rats. Pinacidil decreased the infarct zone in younger female rats, but differences in the type and length of ischemia-induced arrhythmias between females and males disappeared in older age. The results of this study showed that the effect of ATP-dependent potassium channel modulators on ischemia-induced arrhythmia changed due to the age and gender of rats.en_US
dc.description.sponsorshipAbant Izzet Baysal University Research FundAbant Izzet Baysal University [2010.03.01.340]en_US
dc.description.sponsorshipWe thank Abant Izzet Baysal University Research Fund for supporting this study-project number: 2010.03.01.340.en_US
dc.identifier.doi10.1177/1535370213498980en_US
dc.identifier.endpage1179en_US
dc.identifier.issn1535-3702
dc.identifier.issue10en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1170en_US
dc.identifier.urihttps://doi.org/10.1177/1535370213498980
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5680
dc.identifier.volume238en_US
dc.identifier.wosWOS:000324914200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Medicine Press Ltden_US
dc.relation.ispartofExperimental Biology And Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcardiac arrhythmiasen_US
dc.subjectmyocardial ischemiaen_US
dc.subjectcoronary ligationsen_US
dc.subjectglybenclamideen_US
dc.subjectpinacidilen_US
dc.subjectratsen_US
dc.titleEffect of ATP-dependent channel modulators on ischemia-induced arrhythmia change depending on age and genderen_US
dc.typeArticleen_US

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