Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats

dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorBeyazçiçek, Özge
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorDemir, Şerif
dc.contributor.authorÖzmerdivenli, Recep
dc.date.accessioned2020-05-01T09:12:05Z
dc.date.available2020-05-01T09:12:05Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; ankarali, seyit/0000-0003-3752-0846en_US
dc.descriptionWOS: 000385027500005en_US
dc.descriptionPubMed: 27094523en_US
dc.description.abstractObjective: To investigate the effects of thymoquinone (TQ) in a penicillin-induced epilepsy model in rats. Methods: This experimental study included 56 adult male Wistar rats. Experiments were performed in the Research Laboratory of the Department of Physiology, Medical School, Duzce University, Duzce, Turkey, between October 2013 and December 2014. Animals were divided into the following 7 groups: sham, control, only thymoquinone, vehicle (Dimethylsulfoxide), and doses of 10, 50, and 100 mg/kg of TQ. After rats were anesthetized, the left part of the skull was removed. A pair of silver/silver chloride electrodes was placed on the somatomotor area, and electrocorticographic recording was started. After 5 minutes basal activity was recorded, and TQ was applied intraperitoneally. At the thirtieth minute after TQ, epileptiform activity was induced by intracortical penicillin. The first spike latency, spike frequency, and the amplitude of epileptiform activity were analyzed statistically. Results: The different doses of TQ significantly increased the latency time to onset of first spike wave, and decreased the frequency, and amplitude of epileptiform activity in the first 20 minutes compared with the control group. Conclusion: Thymoquinone shows potential as an antiepileptic drug resulting from its effects of prolonged latency time, and reduced spike wave frequency and amplitude of epileptiform activity.en_US
dc.description.sponsorshipCommittee for Scientific Research of Duzce Universityen_US
dc.description.sponsorshipThis study was supported by the Committee for Scientific Research of Duzce University. The authors declare no conflicting interests, support or funding from any drug company.en_US
dc.identifier.doi10.17712/nsj.2016.2.20150781en_US
dc.identifier.endpage137en_US
dc.identifier.issn1319-6138
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.17712/nsj.2016.2.20150781
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5872
dc.identifier.volume21en_US
dc.identifier.wosWOS:000385027500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRiyadh Armed Forces Hospitalen_US
dc.relation.ispartofNeurosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in ratsen_US
dc.typeArticleen_US

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