Association of serum and follicular fluid leptin and ghrelin levels with in vitro fertilization success

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dc.contributor.authorAkarsu, Süleyman
dc.contributor.authorBüke, Barış
dc.contributor.authorGöde, Funda
dc.contributor.authorDirican, Kerem Enver
dc.contributor.authorBaşbuğ, Alper
dc.contributor.authorCeyhan, Seyit Temel
dc.contributor.authorIşık, Ahmet Zeki
dc.date.accessioned2020-04-30T22:39:54Z
dc.date.available2020-04-30T22:39:54Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionDirican, Enver/0000-0001-6230-1229; Gode, Funda/0000-0002-9371-6942; Dirican, Enver/0000-0001-6230-1229en_US
dc.descriptionWOS: 000411999200002en_US
dc.descriptionPubMed: 29949336en_US
dc.description.abstractObjectives: The aim of this study was to evaluate the relationship between in vitro fertilization (IVF) cycle outcomes, serum and follicular fluid (FF) levels of leptin and ghrelin. Material and methods: Forty-four women who underwent intracytoplasmic sperm injection cycles (ICSI) were enrolled in the study. On the third day (D3) of the menstrual cycle, venous blood samples were drawn for serum measurements of leptin and ghrelin. The follicular fluid (FF) and the corresponding oocyte were obtained from a single dominant preovulatory follicle at the time of oocyte pick-up. The FF and D3 serum leptin and ghrelin concentrations were measured by enzyme-linked immunosorbent assay. The relationship between pregnancy rate and serum, follicular fluid levels of leptin and ghrelin were analyzed. Results: Of the 44 cases included, nineteen achieved clinical pregnancy (43.18%). Follicular fluid ghrelin levels were significantly lower in the pregnant group than non-pregnant group (p < 0.05) With respect to FF leptin, there was no statistically significant differences between the pregnant and non-pregnant women (p > 0.05). There was no statistically significant difference in D3 serum ghrelin between pregnant and non-pregnant groups (p > 0.05). However, D3 serum leptin levels were significantly lower in pregnant women than non-pregnant women (p < 0.05). Conclusions: Lower ghrelin levels in the follicular fluid were associated with higher pregnancy rates. Also, D3 serum leptin levels were inversely correlated with clinical pregnancy rates. These findings support the potential role of these molecules on IVF outcomes.en_US
dc.identifier.doi10.5603/GP.a2017.0086en_US
dc.identifier.endpage474en_US
dc.identifier.issn0017-0011
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage469en_US
dc.identifier.urihttps://doi.org/10.5603/GP.a2017.0086
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2857
dc.identifier.volume88en_US
dc.identifier.wosWOS:000411999200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectghrelinen_US
dc.subjectleptinen_US
dc.subjectclinical pregnancyen_US
dc.subjectfollicular fluiden_US
dc.subjectin vitro fertilizationen_US
dc.titleAssociation of serum and follicular fluid leptin and ghrelin levels with in vitro fertilization successen_US
dc.typeArticleen_US

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