Prevention of Pulmonary Complications of Pneumoperitoneum in Rats

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dc.contributor.authorKarapolat, Sami
dc.contributor.authorGezer, Suat
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorDumlu, Talha
dc.contributor.authorKarapolat, Banu
dc.contributor.authorÖzaydın, İsmet
dc.contributor.authorSarıtaş, Ayhan
dc.date.accessioned2020-04-30T23:21:37Z
dc.date.available2020-04-30T23:21:37Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionSaritas, Ayhan/0000-0002-4302-1093;en_US
dc.descriptionWOS: 000287657700001en_US
dc.descriptionPubMed: 21303502en_US
dc.description.abstractBackground: Carbon dioxide (CO(2)) pneumoperitoneum facilitates the visualization of abdominal organs during laparoscopic surgery. However, the associated increase in intra-abdominal pressure causes oxidative stress, which contributes to tissue injury. Objective: We investigated the ability of the antioxidant and anti-inflammatory drug Erdosteine to prevent CO(2) pneumoperitoneum-induced oxidative stress and inflammatory reactions in a rat model. Methods: Fourteen female adult Wistar albino rats were divided into a control group (Group A, n = 7) and an Erdosteine group (Group B, n = 7). Group A received 0.5 cc/day 0.9% NaCl, and Group B received 10 mg/kg/day Erdosteine was administered by gavage, and maintained for 7 days prior to the operation. During the surgical procedure, the rats were exposed to CO(2) pneumoperitoneum with an intra-abdominal pressure of 15 mmHg for 30 min. The peritoneal gas was then desufflated. The rats were sacrificed following 3 h of insufflation. Their lungs were removed, histologically evaluated, and scored for intra-alveolar hemorrhage, alveolar edema, congestion, and leukocyte infiltration. The results were statistically analyzed. A value of P < 0.05 was considered statistically significant. Results: Significant differences were detected in intra-alveolar hemorrhage (P < 0.05), congestion (P < 0.001), and leukocyte infiltration (P < 0.001) in Group A compared with Group B. However, the differences in alveolar edema were not statistically significant (P = 0.698). Conclusions: CO(2) pneumoperitoneum results in oxidative injury to lung tissue, and administration of Erdosteine reduces the severity of pathological changes. Therefore, Erdosteine may be a useful preventive and therapeutic agent for CO(2) pneumoperitoneum-induced oxidative stress in laparoscopic surgery.en_US
dc.identifier.doi10.1186/1749-8090-6-14en_US
dc.identifier.issn1749-8090
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/1749-8090-6-14
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4223
dc.identifier.volume6en_US
dc.identifier.wosWOS:000287657700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofJournal Of Cardiothoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePrevention of Pulmonary Complications of Pneumoperitoneum in Ratsen_US
dc.typeArticleen_US

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