Effects of tenoxicam in experimental corrosive esophagitis model

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dc.contributor.authorErbaş, Mesut
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorKüçük, Adem
dc.contributor.authorTopaloğlu, Naci
dc.contributor.authorErdem, Havva
dc.contributor.authorŞahin, Hasan Can
dc.contributor.authorÖzkan, M. Turgut Alper
dc.date.accessioned2020-05-01T09:12:04Z
dc.date.available2020-05-01T09:12:04Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000352501600009en_US
dc.descriptionPubMed: 24602009en_US
dc.description.abstractEsophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Canakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use.en_US
dc.identifier.doi10.1111/dote.12197en_US
dc.identifier.endpage257en_US
dc.identifier.issn1442-2050
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.1111/dote.12197
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5864
dc.identifier.volume28en_US
dc.identifier.wosWOS:000352501600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofDiseases Of The Esophagusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaustic esophageal burnen_US
dc.subjecttenoxicamen_US
dc.subjecttreatmenten_US
dc.titleEffects of tenoxicam in experimental corrosive esophagitis modelen_US
dc.typeArticleen_US

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