Effect of Strontium Ranelate on Fracture Healing in the Osteoporotic Rats

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dc.contributor.authorÖzturan, Kutay Engin
dc.contributor.authorDemir, Berfu
dc.contributor.authorYücel, İstemi
dc.contributor.authorÇakıcı, Hüsamettin
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorHaberal, Ali
dc.date.accessioned2020-05-01T09:11:47Z
dc.date.available2020-05-01T09:11:47Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description65th Congress on American-Society-Reproductive-Medicine (ASRM) -- OCT 17-21, 2009 -- Atlanta, GAen_US
dc.descriptionWOS: 000285321900022en_US
dc.descriptionPubMed: 20726035en_US
dc.description.abstractThe aim of this study was to evaluate the effect of strontium ranelate (SrR) on fracture healing in the osteoporotic rat model. Forty female Sprague Dawley rats aged 3 months were enrolled in the study. Osteoporosis was induced by bilateral ovariectomy and subsequent daily heparin injection started 1 week after surgery and lasted for 4 weeks. Osteoporosis was confirmed by a reduction of bone mineral density (BMD). Twenty of the osteoporotic rats were assigned to the SrR group and the remaining 20 to the control group. An open right tibial midshaft transverse fracture was created and then an intramedullary fixation was performed. SrR group was treated by 450 mg/kg/day SrR per oral. Six weeks after surgical induction of fracture, all animals were sacrificed. One animal from each group died after ovariectomy. Two tibiae from the control group failed to unite. SrR-treated group showed higher mechanical strength and fracture stiffness when compared to the control group (p = 0.006, p = 0.001, respectively). SrR-treated group had mature woven bone or predominantly woven bone compared with osteoporotic control group (p = 0.038). SrR-treated group's callus maturity was significantly higher than control group (p = 0.001). SrR is associated with better fracture healing in the osteoporotic rat model. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29: 138-142, 2011en_US
dc.description.sponsorshipAmer Soc Reproduct Med (ASRM)en_US
dc.identifier.doi10.1002/jor.21204en_US
dc.identifier.endpage142en_US
dc.identifier.issn0736-0266
dc.identifier.issn1554-527X
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage138en_US
dc.identifier.urihttps://doi.org/10.1002/jor.21204
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5764
dc.identifier.volume29en_US
dc.identifier.wosWOS:000285321900022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Orthopaedic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectstrontium ranelateen_US
dc.subjectfracture healingen_US
dc.subjectosteoporosisen_US
dc.subjectovariectomized raten_US
dc.subjectheparinen_US
dc.titleEffect of Strontium Ranelate on Fracture Healing in the Osteoporotic Ratsen_US
dc.typeArticleen_US

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