Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

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dc.contributor.authorTopaloğlu, Naci
dc.contributor.authorKüçük, Adem
dc.contributor.authorYıldırım, Şule
dc.contributor.authorTekin, Mustafa
dc.contributor.authorErdem, Havva
dc.contributor.authorDeniz, Mustafa
dc.date.accessioned2020-05-01T12:10:15Z
dc.date.available2020-05-01T12:10:15Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionYildirim, Sule/0000-0002-1815-808Xen_US
dc.descriptionWOS: 000368445200012en_US
dc.descriptionPubMed: 26290282en_US
dc.description.abstractGlucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 mu g GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P < 0.001), whereas GLP-2 pretreatment significantly decreased their levels (P < 0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.en_US
dc.identifier.doi10.1007/s11684-015-0403-1en_US
dc.identifier.endpage373en_US
dc.identifier.issn2095-0217
dc.identifier.issn2095-0225
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage368en_US
dc.identifier.urihttps://doi.org/10.1007/s11684-015-0403-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6106
dc.identifier.volume9en_US
dc.identifier.wosWOS:000368445200012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofFrontiers Of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia/reperfusionen_US
dc.subjectliveren_US
dc.subjectglucagon-like peptide-2en_US
dc.subjectalanine aminotransferaseen_US
dc.titleGlucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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