The effect of vortioxetine on penicillin-induced epileptiform activity in rats

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dc.contributor.authorOgün, Muhammed Nur
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorBeyazçiçek, Ersin
dc.date.accessioned2020-04-30T23:33:14Z
dc.date.available2020-04-30T23:33:14Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionogun, muhammed nur/0000-0001-5524-5767; CETINKAYA, AYHAN/0000-0002-8212-7149en_US
dc.descriptionWOS: 000475498800007en_US
dc.descriptionPubMed: 31314843en_US
dc.description.abstractVortioxetine is a multimodal antidepressant agent that modulates 5-HT receptors and inhibits the serotonin transporter. It is indicated especially in cases of major depressive disorder related to cognitive dysfunction. There are many studies investigating the effects of antidepressants on the seizure threshold and short-term epileptic activity. However, the effect of vortioxetine on epileptic seizures is not exactly known. Our aim was to investigate the effects of vortioxetine on penicillin-induced epileptiform activity. Twenty-seven Wistar rats were divided into three groups: sham-control group, positive control group (diazepam), and vortioxetine group. After a penicillin-induced epilepsy model was formed in each of the three groups of animals, 0.1 ml of saline was administered to the control group, 0.1 ml (10 mg/kg) vortioxetine was administered in the vortioxetine group, and 0.1 mL (5 mg/kg) of diazepam was administered in the positive control group, intraperitoneally. The epileptic activity records were obtained for 120 minutes after the onset of seizure.There was no significant difference in spike wave activity between the vortioxetine and diazepam groups, whereas this was significantly reduced in the vortioxetine group compared with the controls. The administration of vortioxetine at a dose of 10 mg/kg immediately after the seizure induction significantly decreased the spike frequencies of epileptiform activity compared with the control group. No significant difference was found between the vortioxetine and positive controls.This study showed that vortioxetine reduces the number of acutely-induced epileptic discharges. Vortioxetine may be an important alternative for epileptic patients with major depressive disorder-related cognitive dysfunction.en_US
dc.identifier.doi10.1590/0004-282X20190064en_US
dc.identifier.endpage417en_US
dc.identifier.issn0004-282X
dc.identifier.issn1678-4227
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage412en_US
dc.identifier.urihttps://doi.org/10.1590/0004-282X20190064
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4927
dc.identifier.volume77en_US
dc.identifier.wosWOS:000475498800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAssoc Arquivos Neuro- Psiquiatriaen_US
dc.relation.ispartofArquivos De Neuro-Psiquiatriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpilepsyen_US
dc.subjectpenicillinsen_US
dc.subjectvortioxetineen_US
dc.subjectratsen_US
dc.titleThe effect of vortioxetine on penicillin-induced epileptiform activity in ratsen_US
dc.typeArticleen_US

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