Protective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in rats

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dc.contributor.authorKüçük, Adem
dc.contributor.authorTopaloğlu, Naci
dc.contributor.authorYıldırım, Şule
dc.contributor.authorTekin, Mustafa
dc.contributor.authorErbaş, Mesut
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorÖzkan, Aybars
dc.date.accessioned2020-04-30T23:21:52Z
dc.date.available2020-04-30T23:21:52Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionYildirim, Sule/0000-0002-1815-808Xen_US
dc.descriptionWOS: 000398426800016en_US
dc.descriptionPubMed: 28447968en_US
dc.description.abstractAccidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group 7; n:8), control group (Group K n: 8) and sham group (Group S, n: 8). In group T and S corrosive esophagitis was induced. UDCA (5 mg/kg) was performed to the group T for 10 days orally. All animals were sacrificed at the end of procedures and histopathological changes in esophageal tissue were scored by a single investigator who was blind to the groups. In group T inflammation was present in two rats, muscularis mucosa injury in two rats, grade I collagen deposition in six rats and grade 2 in two rats. In comparison with group S these were statistically significant (p value was 0.003, 0.003 and 0.015, respectively). UDCA has protective effect in experimental corrosive esophagitis.en_US
dc.identifier.endpage86en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue1en_US
dc.identifier.startpage82en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4263
dc.identifier.volume88en_US
dc.identifier.wosWOS:000398426800016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani Di Chirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorrosive esophagitisen_US
dc.subjectRaten_US
dc.subjectStrictureen_US
dc.subjectUrsodeoxycholic aciden_US
dc.titleProtective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in ratsen_US
dc.typeArticleen_US

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