Protective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in rats
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Edizioni Luigi Pozzi
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Accidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group 7; n:8), control group (Group K n: 8) and sham group (Group S, n: 8). In group T and S corrosive esophagitis was induced. UDCA (5 mg/kg) was performed to the group T for 10 days orally. All animals were sacrificed at the end of procedures and histopathological changes in esophageal tissue were scored by a single investigator who was blind to the groups. In group T inflammation was present in two rats, muscularis mucosa injury in two rats, grade I collagen deposition in six rats and grade 2 in two rats. In comparison with group S these were statistically significant (p value was 0.003, 0.003 and 0.015, respectively). UDCA has protective effect in experimental corrosive esophagitis.
Description
Yildirim, Sule/0000-0002-1815-808X
WOS: 000398426800016
PubMed: 28447968
WOS: 000398426800016
PubMed: 28447968
Keywords
Corrosive esophagitis, Rat, Stricture, Ursodeoxycholic acid
Journal or Series
Annali Italiani Di Chirurgia
WoS Q Value
Q4
Scopus Q Value
Volume
88
Issue
1
