Should Cut-Off Values of the Risk of Malignancy Index be Changed for Evaluation of Adnexal Masses in Asian and Pacific Populations?

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dc.contributor.authorYavuzcan, Ali
dc.contributor.authorÇağlar, Mete
dc.contributor.authorÖzgü, Emre
dc.contributor.authorÜstün, Yusuf
dc.contributor.authorDilbaz, Serdar
dc.contributor.authorÖzdemir, İsmail
dc.contributor.authorKumru, Selahattin
dc.date.accessioned2020-04-30T23:31:56Z
dc.date.available2020-04-30T23:31:56Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKUMRU, Selahattin/0000-0001-6615-7666; Ozgu, Emre/0000-0002-8444-9694; Gungor, Tayfun/0000-0002-7869-9662en_US
dc.descriptionWOS: 000328273000086en_US
dc.descriptionPubMed: 24175841en_US
dc.description.abstractBackground: The risk of malignancy index (RMI) for the evaluation of adnexal masses is a sensitive tool in certain populations. The best cut off value for RMI 1, 2 and 3 is 200. The cut off value of RMI-4 to differentiate benign from malignant lesions is 450. Our aim was to evaluate the efficiency of four different malignancy indexes (RMI1-4) in a homogeneous population. Materials and Methods: We evaluated a total of 153 non-pregnant women with adnexal masses who did not have a history of malignancy and who were above 18 years of age. Results: A cut-off value of 250 for RMI-1 provided 95.9% inter-observer agreement, yielding 95.9% specificity, 93.5% negative predictive value, 75.0% sensitivity and 82.8% positive predictive value. A cut-off value of 250 for RMI-1 showed high performance in preoperative diagnosis of invasive malignant lesions than cut-off value of 200 in our population. A cut-off value of 350 for RMI-2 provided 94.5% inter-observed agreement, yielding 94.2% specificity, 93.4% negative predictive value, 75.0% sensitivity and 77.4% positive predictive value. RMI-2 showed the higher performance when the cut-off value was set at 350 in our population. A cut-off value of 250 provided 95.2% inter-observer agreement, yielding 95.0% specificity, 93.2% negative predictive value, 75.0% sensitivity, and 88.0% positive predictive value. RMI-3 showed the highest performance to diagnose malignant adnexal masses when the cut-off value was set at 250. In our study, RMI-4 showed similar statistical performance when the cut-off value was set at 400 [(Kappa: 0.684/p=0.000), yielding 93.8% inter-observer agreement, 93.4% specificity, 93.4% negative predictive value, 75.0% sensitivity, and 75.0% negative predictive value]. Conclusions: We showed successful utilization of RMIs in preoperative differentiation of benign from malignant masses. Many studies conducted in Asian and Pacific countries have reported different cut-off values as was the case in our study. We think that it is difficult to determine universally accepted cut-off values for RMIs for common use around the globe.en_US
dc.identifier.doi10.7314/APJCP.2013.14.9.5455
dc.identifier.endpage5459en_US
dc.identifier.issn1513-7368
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage5455en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.9.5455
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4540
dc.identifier.volume14en_US
dc.identifier.wosWOS:000328273000086en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal Of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdnexal massen_US
dc.subjectovarian canceren_US
dc.subjectrisk of malignancy indexen_US
dc.titleShould Cut-Off Values of the Risk of Malignancy Index be Changed for Evaluation of Adnexal Masses in Asian and Pacific Populations?en_US
dc.typeArticleen_US

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