Experimental Esophagitis Model Preventing Tracheal Aspiration

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dc.contributor.authorKiraz, Hasan A.
dc.contributor.authorErbaş, Mesut
dc.contributor.authorKüçük, Adem
dc.contributor.authorTopaloğlu, Naci
dc.contributor.authorErdem, Havva
dc.contributor.authorŞahin, Hasan
dc.contributor.authorKiraz, Aslı
dc.date.accessioned2020-05-01T12:14:14Z
dc.date.available2020-05-01T12:14:14Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000360287300011en_US
dc.descriptionPubMed: 26469108en_US
dc.description.abstractBackground. Corrosive esophagitis injuries are a serious clinical problem with many agents used for diagnosis and treatment. Experimental esophagus burn models use a method described mainly in studies by Gehanno and Guedon, and modified by Liu and Richardson. Objectives. The aim of this study was to describe a new esophagitis model that prevents tracheal aspiration. Material and Methods. In this study we used 16 Wistar albino rats weighing between 220-240 g. The experimental animals were randomly divided into two groups: the model group (group M, n: 8) and control group (group C, n: 8). The necessary anesthesia was administered. Passing through a median laparotomy incision, the abdomen was entered and in group M and C the esophagus was freed and held by a suture at the gastroesophageal junction. After this procedure, about 1 cm proximal to the gastroesophageal junction, the esophagus was suspended by a suture. The esophagus segment between the two sutures was exposed to 0.1 mL 10% NaOH in group M and 0.1 mL saline in group C for 20 s. Ten days later all experimental animals were sacrificed and their esophagus removed. After dying with hematoxylin and eosine trichrome, the histopathological evaluation results for the rats in all groups were investigated with a light microscope. Results. Histopathological examination indicated submucosal collagen increase, damage to muscularis mucosa and tunica muscularis and collagen deposition. In the model group, the rats had high neutrophils and tissue damage accompanied by necrosis. In the control group, the rats had minimal or no tissue damage and fibrosis was not observed. Conclusions. Our procedure is relatively less invasive and easy to apply with corrosive esophagitis only in the required region, and at the same time treatment medications can be easily administered.en_US
dc.identifier.doi10.17219/acem/22364en_US
dc.identifier.endpage641en_US
dc.identifier.issn1899-5276
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage637en_US
dc.identifier.urihttps://doi.org/10.17219/acem/22364
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6364
dc.identifier.volume24en_US
dc.identifier.wosWOS:000360287300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances In Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectexperimental modelen_US
dc.subjectcorrosive esophagitisen_US
dc.subjectNaOHen_US
dc.subjecttracheal aspirationen_US
dc.titleExperimental Esophagitis Model Preventing Tracheal Aspirationen_US
dc.typeArticleen_US

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