IMPACT OF NUTRITIONAL STATUS IN SARCOIDOSIS PATIENTS

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dc.contributor.authorTunc, Seyma
dc.contributor.authorYildiz, Pinar
dc.contributor.authorSungur, Mehmet ali
dc.date.accessioned2026-07-01T11:39:17Z
dc.date.available2026-07-01T11:39:17Z
dc.date.issued2025
dc.departmentDüzce Üniversitesi
dc.description.abstractBackground and aim: Sarcoidosis is a systemic granulomatous disease of unknown etiology, and fatigue is among its most common complaints. The underlying cause of fatigue remains under investigation. Factors such as reduced pulmonary function, impaired respiratory muscle strength, physical deconditioning, and corticosteroidinduced myopathy may contribute to fatigue. The importance of evaluating nutritional status in patients with respiratory system diseases is increasingly recognized. This study aimed to investigate the impact of nutritional assessment on peripheral muscle strength, respiratory muscle strength, and exercise capacity in patients with sarcoidosis. Methods: This prospective case-control study included 31 sarcoidosis patients not receiving systemic steroid therapy and 24 age-and sex-matched healthy controls. Participants underwent assessments of functional exercise capacity using the 6-minute walk test (6MWT), respiratory muscle strength via maximal inspiratory (MIP) and expiratory pressures (MEP), peripheral muscle strength via handgrip dynamometry, and pulmonary function testing. Nutritional status was evaluated using the Mini Nutritional Assessment (MNA) questionnaire and body composition analysis via bioelectrical impedance. Results: Despite similar pulmonary function and respiratory muscle strength, sarcoidosis patients demonstrated significantly lower 6MWT distances compared to controls. Body mass index (BMI) and fat mass were significantly higher in the sarcoidosis group. Lean mass, soft tissue mass, skeletal muscle mass, total body water, and peripheral muscle strength were similar between the two groups. No significant differences were found between groups in MIP, MEP, or their predicted percentages. Positive correlations were observed between MIP, MEP, and lean body mass, while fat mass was negatively correlated with peak expiratory flow (PEF). Conclusions: This study underscores the importance of individualized interventions for fatigue management in sarcoidosis, not only by addressing underlying inflammation but also by incorporating lifestyle modifications, nutritional optimization, and physical rehabilitation. In our findings, BMI and fat mass were significantly higher in sarcoidosis patients compared to controls. These results suggest that further research is warranted to explore the role of fat-related inflammation in the progression and outcomes of sarcoidosis.
dc.identifier.doi10.36141/svdld.v42i3.16968
dc.identifier.issn1124-0490
dc.identifier.issue3
dc.identifier.pmid41026024
dc.identifier.scopus2-s2.0-105018085784
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.36141/svdld.v42i3.16968
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23209
dc.identifier.volume42
dc.identifier.wosWOS:001587922900013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMattioli 1885
dc.relation.ispartofSarcoidosis Vasculitis and Diffuse Lung Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260623
dc.subjectSarcoidosis
dc.subjectNutritional Status
dc.subjectRespiratory Muscle Strength
dc.subjectFatigue
dc.titleIMPACT OF NUTRITIONAL STATUS IN SARCOIDOSIS PATIENTS
dc.typeArticle

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