IMPACT OF NUTRITIONAL STATUS IN SARCOIDOSIS PATIENTS
Küçük Resim Yok
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mattioli 1885
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and aim: Sarcoidosis is a systemic granulomatous disease of unknown etiology, and fatigue is among its most common complaints. The underlying cause of fatigue remains under investigation. Factors such as reduced pulmonary function, impaired respiratory muscle strength, physical deconditioning, and corticosteroidinduced myopathy may contribute to fatigue. The importance of evaluating nutritional status in patients with respiratory system diseases is increasingly recognized. This study aimed to investigate the impact of nutritional assessment on peripheral muscle strength, respiratory muscle strength, and exercise capacity in patients with sarcoidosis. Methods: This prospective case-control study included 31 sarcoidosis patients not receiving systemic steroid therapy and 24 age-and sex-matched healthy controls. Participants underwent assessments of functional exercise capacity using the 6-minute walk test (6MWT), respiratory muscle strength via maximal inspiratory (MIP) and expiratory pressures (MEP), peripheral muscle strength via handgrip dynamometry, and pulmonary function testing. Nutritional status was evaluated using the Mini Nutritional Assessment (MNA) questionnaire and body composition analysis via bioelectrical impedance. Results: Despite similar pulmonary function and respiratory muscle strength, sarcoidosis patients demonstrated significantly lower 6MWT distances compared to controls. Body mass index (BMI) and fat mass were significantly higher in the sarcoidosis group. Lean mass, soft tissue mass, skeletal muscle mass, total body water, and peripheral muscle strength were similar between the two groups. No significant differences were found between groups in MIP, MEP, or their predicted percentages. Positive correlations were observed between MIP, MEP, and lean body mass, while fat mass was negatively correlated with peak expiratory flow (PEF). Conclusions: This study underscores the importance of individualized interventions for fatigue management in sarcoidosis, not only by addressing underlying inflammation but also by incorporating lifestyle modifications, nutritional optimization, and physical rehabilitation. In our findings, BMI and fat mass were significantly higher in sarcoidosis patients compared to controls. These results suggest that further research is warranted to explore the role of fat-related inflammation in the progression and outcomes of sarcoidosis.
Açıklama
Anahtar Kelimeler
Sarcoidosis, Nutritional Status, Respiratory Muscle Strength, Fatigue
Kaynak
Sarcoidosis Vasculitis and Diffuse Lung Diseases
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
42
Sayı
3
