Phosalone Toxicity on Liver and Pancreas: Role of Vitamins E and C

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dc.contributor.authorDemirin, Hilmi
dc.contributor.authorGökalp, Osman
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorBüyükvanlı, Bora
dc.contributor.authorCesur, Gökhan
dc.contributor.authorÖzkan, Aybars
dc.contributor.authorKaya, Murat
dc.date.accessioned2020-04-30T23:20:55Z
dc.date.available2020-04-30T23:20:55Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionKaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000317245800051en_US
dc.description.abstractPhosalone (6-chloro-3-[diethoxyphosphinothioylsulfanylmethyl]-1,3-benzoxazol-2-one) is one of the most commonly used organophosphorus pesticides in the peat control of crops. Subchronic phosalone exposure was evaluated for its effects on the serum activities of some enzymes concerning hepatic and pancreatic damage including aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyltransferase (GGT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), cholinesterase (ChE); and finally protective effects of combination of vitamins E and C in 24 wistar-albino rats. Experimental groups were as follows: control group (n = 8); a group treated with 120 mg/kg body weight phosalone (P group, n = 8); and a group treated with 120 mg/kg body weight phosalone + vitamin E + vitamin C (P+V group, n = 8). The P and P+V groups were treated orally with phosalone on 5 days a week for 4 weeks. The serum activities of the above mentioned enzymes were analyzed. In the samples phosalone significantly increased the activities of ALT, LDH and decreased ChE (p < 0.05). However no significant change was detected for the remainder enzymes (p > 0.05). In the P+V group, ALT and LDH activities were significantly increased and ChE decreased (p < 0.05). It is concluded that subchronic phosalone causes rat liver damage to an extent, which is somewhat reflected on the liver enzymes. Furthermore, a combination of vitamins E and C can reduce the toxic effects of phosalone on liver tissue of rats.en_US
dc.identifier.doi10.14233/ajchem.2013.13487en_US
dc.identifier.endpage2592en_US
dc.identifier.issn0970-7077
dc.identifier.issn0975-427X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage2589en_US
dc.identifier.urihttps://doi.org/10.14233/ajchem.2013.13487
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4102
dc.identifier.volume25en_US
dc.identifier.wosWOS:000317245800051en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Journal Of Chemistryen_US
dc.relation.ispartofAsian Journal Of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhosaloneen_US
dc.subjectToxicityen_US
dc.subjectLiveren_US
dc.subjectPancreasen_US
dc.subjectEnzymeen_US
dc.titlePhosalone Toxicity on Liver and Pancreas: Role of Vitamins E and Cen_US
dc.typeArticleen_US

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