Phosalone Toxicity on Liver and Pancreas: Role of Vitamins E and C
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Asian Journal Of Chemistry
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Phosalone (6-chloro-3-[diethoxyphosphinothioylsulfanylmethyl]-1,3-benzoxazol-2-one) is one of the most commonly used organophosphorus pesticides in the peat control of crops. Subchronic phosalone exposure was evaluated for its effects on the serum activities of some enzymes concerning hepatic and pancreatic damage including aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyltransferase (GGT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), cholinesterase (ChE); and finally protective effects of combination of vitamins E and C in 24 wistar-albino rats. Experimental groups were as follows: control group (n = 8); a group treated with 120 mg/kg body weight phosalone (P group, n = 8); and a group treated with 120 mg/kg body weight phosalone + vitamin E + vitamin C (P+V group, n = 8). The P and P+V groups were treated orally with phosalone on 5 days a week for 4 weeks. The serum activities of the above mentioned enzymes were analyzed. In the samples phosalone significantly increased the activities of ALT, LDH and decreased ChE (p < 0.05). However no significant change was detected for the remainder enzymes (p > 0.05). In the P+V group, ALT and LDH activities were significantly increased and ChE decreased (p < 0.05). It is concluded that subchronic phosalone causes rat liver damage to an extent, which is somewhat reflected on the liver enzymes. Furthermore, a combination of vitamins E and C can reduce the toxic effects of phosalone on liver tissue of rats.
Açıklama
Kaya, Ertugrul/0000-0003-0081-682X
WOS: 000317245800051
WOS: 000317245800051
Anahtar Kelimeler
Phosalone, Toxicity, Liver, Pancreas, Enzyme
Kaynak
Asian Journal Of Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
25
Sayı
5
