Ocular abnormalities in morbid obesity

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dc.contributor.authorTeberik, Kuddusi
dc.contributor.authorEski, Mehmet Tahir
dc.contributor.authorDoğan, Sami
dc.contributor.authorPehlivan, Mevlüt
dc.contributor.authorKaya, Murat
dc.date.accessioned2020-04-30T23:19:50Z
dc.date.available2020-04-30T23:19:50Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000455788400003en_US
dc.descriptionPubMed: 30652762en_US
dc.description.abstractPurpose:Obesity is associated with eye diseases, but the underlying structural changes and pathogenic mechanisms have not been examined in detail. Here, we assessed the effects of morbid obesity on the morphometric indices of eye disease. Methods: Morbidly obese volunteers (n=101, body mass index [BMI] >= 40) and healthy individuals (n=95, BMI: 18.50-24.99) were examined by Goldman applanation tonometry, pachymetry, and spectral domain optical coherence tomography. Intraocular pressure, anterior chamber depth, axial length, central corneal thickness, retinal nerve fiber layer thickness, central fovea! thickness, and choroidal thickness were compared between groups. Results: Uncorrected intraocular pressure was significantly greater in the morbidly obese group than in the healthy control group (15.5 +/- 2.5 vs. 14.5 +/- 2.6 mmHg, p=0.009), whereas axial length, anterior chamber depth, and central corneal thickness did not differ between the groups. The mean retinal nerve fiber layer thickness at the temporal quadrant was reduced in the morbidly obese group (72.7 +/- 13.6 vs. 85.05 +/- 52.6 mu m, p=0.024). Similarly, the mean retinal thicknesses at nasal and temporal 1500-mu m locations were lower in the morbidly obese group (346.6 +/- 18.2 vs. 353.7 +/- 18.8 mu m, p=0.008; 323.1 +/- 20.3 vs. 330.0 +/- 18.9 mu m, p=0.001). The mean choroidal thickness was also reduced in almost all measurement locations (fovea, temporal 500 and 1000 mu m, and nasal 500, 1000, and 1500 mu m) of the obese group (p <0.05). Weight and BMI were negatively correlated with subfoveal choroidal thickness (r=-0.186, p=0.009; r=-0.173, p=0.015). Conclusion: Morbid obesity is associated with elevated uncorrected intraocular pressure and signs of neuropathy and retinopathy. Obesity may thus increase the risks of glaucoma and glaucomatous optic neuropathy.en_US
dc.identifier.doi10.5935/0004-2749.20190007en_US
dc.identifier.endpage11en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20190007
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3864
dc.identifier.volume82en_US
dc.identifier.wosWOS:000455788400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherConsel Brasil Oftalmologiaen_US
dc.relation.ispartofArquivos Brasileiros De Oftalmologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMorbid obesityen_US
dc.subjectIntraocular pressureen_US
dc.subjectNerve fibersen_US
dc.subjectCorneal pachymetryen_US
dc.subjectAnterior eye segmenten_US
dc.subjectPosterior eye segmenten_US
dc.titleOcular abnormalities in morbid obesityen_US
dc.typeArticleen_US

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