Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents

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dc.contributor.authorAliağaoğlu, Cihangir
dc.contributor.authorTuran, Hakan
dc.contributor.authorErden, İsmail
dc.contributor.authorAlbayrak, Hülya
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorBaşar, Cengiz
dc.contributor.authorAlçelik, Ayşegül
dc.date.accessioned2020-04-30T23:31:36Z
dc.date.available2020-04-30T23:31:36Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAlcelik, Aytekin/0000-0002-3156-1076en_US
dc.descriptionWOS: 000311462400007en_US
dc.descriptionPubMed: 23197908en_US
dc.description.abstractBackground: In-stent restenosis (ISR) is the major limitation of percutaneous coronary stenting procedure. The elements like nickel, chromate and molybdenum are known to cause contact allergy. Hypersensitivity reaction, against these metal ions, may be one of the reasons of ISR. Cobalt chromium coronary stents, which are increasingly being used in percutaneous coronary interventions, have more nickel amount than the stainless steel stents. Objective: We aimed to investigate the association between nickel hypersensitivity reaction and ISR in patients treated with cobalt chromium coronary stents. Methods: Epicutaneous patch tests for nickel were applied to 31 patients who had undergone elective cobalt chromium coronary stent implantation and had ISR in control angiogram. Thirty patients, without ISR, were included as the control group. Patch test results and other clinical variables were compared. Results: There was no statistically significant difference of the mean age, sex, body mass index, rate of hypercholesterolemia, diabetes, hypertension and smoking between the patients with and without ISR. All other lesion characteristics were similar in the 2 groups. According to the patch test results, 7 patients had nickel contact allergy. All of these patients were in the ISR group, which was statistically significant (p < 0.006). Conclusion: Patients treated with cobalt chromium coronary stents and had ISR were found to have significantly more nickel allergy than the control group. Nickel allergy may play role in restenosis pathophysiology. (Ann Dermatol 24(4) 426 similar to 429, 2012)en_US
dc.identifier.doi10.5021/ad.2012.24.4.426en_US
dc.identifier.endpage429en_US
dc.identifier.issn1013-9087
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage426en_US
dc.identifier.urihttps://doi.org/10.5021/ad.2012.24.4.426
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4343
dc.identifier.volume24en_US
dc.identifier.wosWOS:000311462400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKorean Dermatological Assocen_US
dc.relation.ispartofAnnals Of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllergy and immunologyen_US
dc.subjectCoronary restenosisen_US
dc.subjectPatch testsen_US
dc.titleRelation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stentsen_US
dc.typeArticleen_US

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