Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Dermatological Assoc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: In-stent restenosis (ISR) is the major limitation of percutaneous coronary stenting procedure. The elements like nickel, chromate and molybdenum are known to cause contact allergy. Hypersensitivity reaction, against these metal ions, may be one of the reasons of ISR. Cobalt chromium coronary stents, which are increasingly being used in percutaneous coronary interventions, have more nickel amount than the stainless steel stents. Objective: We aimed to investigate the association between nickel hypersensitivity reaction and ISR in patients treated with cobalt chromium coronary stents. Methods: Epicutaneous patch tests for nickel were applied to 31 patients who had undergone elective cobalt chromium coronary stent implantation and had ISR in control angiogram. Thirty patients, without ISR, were included as the control group. Patch test results and other clinical variables were compared. Results: There was no statistically significant difference of the mean age, sex, body mass index, rate of hypercholesterolemia, diabetes, hypertension and smoking between the patients with and without ISR. All other lesion characteristics were similar in the 2 groups. According to the patch test results, 7 patients had nickel contact allergy. All of these patients were in the ISR group, which was statistically significant (p < 0.006). Conclusion: Patients treated with cobalt chromium coronary stents and had ISR were found to have significantly more nickel allergy than the control group. Nickel allergy may play role in restenosis pathophysiology. (Ann Dermatol 24(4) 426 similar to 429, 2012)
Açıklama
Alcelik, Aytekin/0000-0002-3156-1076
WOS: 000311462400007
PubMed: 23197908
WOS: 000311462400007
PubMed: 23197908
Anahtar Kelimeler
Allergy and immunology, Coronary restenosis, Patch tests
Kaynak
Annals Of Dermatology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
24
Sayı
4
