A Case Study: What Doses of Amanita phalloides and Amatoxins Are Lethal to Humans?

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dc.contributor.authorYılmaz, İsmail
dc.contributor.authorErmiş, Fatih
dc.contributor.authorAkata, Ilgaz
dc.contributor.authorKaya, Ertuğrul
dc.date.accessioned2020-04-30T22:38:37Z
dc.date.available2020-04-30T22:38:37Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKaya, Ertugrul/0000-0003-0081-682X; Akata, Ilgaz/0000-0002-1731-1302en_US
dc.descriptionWOS: 000366228200006en_US
dc.descriptionPubMed: 26453489en_US
dc.description.abstractThere are few data estimating the human lethal dose of amatoxins or of the toxin level present in ingested raw poisonous mushrooms. Here, we present a patient who intentionally ingested several wild collected mushrooms to assess whether they were poisonous. Nearly 1 day after ingestion, during which the patient had nausea and vomiting, he presented at the emergency department. His transaminase levels started to increase starting from hour 48 and peaking at hour 72 (alanine aminotransferase 2496 IU/L; aspartate aminotransferase 1777 IU/L). A toxin analysis was carried out on the mushrooms that the patient said he had ingested. With reversed-phase high-performance liquid chromatography analysis, an uptake of approximately 21.3 mg amatoxin from nearly 50 g mushroom was calculated; it consisted of 11.9 mg alpha amanitin, 8.4 mg beta amanitin, and 1 mg gamma amanitin In the urine sample taken on day 4, 2.7 ng/mL alpha amanitin and 1.25 ng/mL beta amanitin were found, and there was no gamma amanitin. Our findings suggest that the patient ingested approximately 0.32 mg/kg amatoxin, and fortunately recovered after serious hepatotoxicity developed.en_US
dc.identifier.doi10.1016/j.wem.2015.08.002en_US
dc.identifier.endpage496en_US
dc.identifier.issn1080-6032
dc.identifier.issn1545-1534
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage491en_US
dc.identifier.urihttps://doi.org/10.1016/j.wem.2015.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2308
dc.identifier.volume26en_US
dc.identifier.wosWOS:000366228200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWilderness & Environmental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmanita phalloidesen_US
dc.subjectamanitinen_US
dc.subjectsublethal toxicityen_US
dc.subjecthigh-performance liquid chromatographyen_US
dc.titleA Case Study: What Doses of Amanita phalloides and Amatoxins Are Lethal to Humans?en_US
dc.typeArticleen_US

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