A Case Study: What Doses of Amanita phalloides and Amatoxins Are Lethal to Humans?
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Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
There are few data estimating the human lethal dose of amatoxins or of the toxin level present in ingested raw poisonous mushrooms. Here, we present a patient who intentionally ingested several wild collected mushrooms to assess whether they were poisonous. Nearly 1 day after ingestion, during which the patient had nausea and vomiting, he presented at the emergency department. His transaminase levels started to increase starting from hour 48 and peaking at hour 72 (alanine aminotransferase 2496 IU/L; aspartate aminotransferase 1777 IU/L). A toxin analysis was carried out on the mushrooms that the patient said he had ingested. With reversed-phase high-performance liquid chromatography analysis, an uptake of approximately 21.3 mg amatoxin from nearly 50 g mushroom was calculated; it consisted of 11.9 mg alpha amanitin, 8.4 mg beta amanitin, and 1 mg gamma amanitin In the urine sample taken on day 4, 2.7 ng/mL alpha amanitin and 1.25 ng/mL beta amanitin were found, and there was no gamma amanitin. Our findings suggest that the patient ingested approximately 0.32 mg/kg amatoxin, and fortunately recovered after serious hepatotoxicity developed.
Açıklama
Kaya, Ertugrul/0000-0003-0081-682X; Akata, Ilgaz/0000-0002-1731-1302
WOS: 000366228200006
PubMed: 26453489
WOS: 000366228200006
PubMed: 26453489
Anahtar Kelimeler
Amanita phalloides, amanitin, sublethal toxicity, high-performance liquid chromatography
Kaynak
Wilderness & Environmental Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
26
Sayı
4
