The Effect of Etanercept on Spinal Epidural Fibrosis in a Postlaminectomy Rat Model

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dc.contributor.authorTürkoğlu, Erhan
dc.contributor.authorTuncer, Cengiz
dc.contributor.authorDinç, Cem
dc.contributor.authorSerbes, Gökhan
dc.contributor.authorOktay, Murat
dc.contributor.authorŞekerci, Zeki
dc.date.accessioned2020-04-30T23:32:55Z
dc.date.available2020-04-30T23:32:55Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000340227300011en_US
dc.descriptionPubMed: 25050674en_US
dc.description.abstractAIM: The formation of epidural fibrosis adjacent to the dura mater after posterior spinal surgery is a normal reaction of the body to surgery. Extensive epidural fibrosis is one of the important causes of postlaminectomy syndrome. Etanercept inhibits tumor necrosis factor-alpha and decreases fibroblast migration. Thus, etanercept prevents the formation of fibrosis. The aim of this study was to investigate the effects of topical application of etanercept on epidural fibrosis after laminectomy in a rat model. MATERIAL and METHODS:Twenty-four Wistar rats were equally and randomly divided into three groups (control, spongostan and etanercept). Laminectomy was performed between L3 and L5 in all the rats. Spongostan soaked with saline (0.1 mg/kg) and etanercept (300 mu g/kg) was directly exposed to and left on the dura mater. Four weeks later, the vertebral columns of the rats were removed en bloc between T10 and L5, and epidural fibrosis and arachnoidal involvement were evaluated and graded histopathologically. RESULTS: Our data revealed that epidural fibrosis was reduced significantly in the rats treated with etanercept, compared to the control groups (p<0.05). CONCLUSION: Our study demonstrated that topical application of etanercept can be effective in reducing epidural fibrosis in rats after laminectomy.en_US
dc.identifier.doi10.5137/1019-5149.JTN.9006-13.1en_US
dc.identifier.endpage511en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage506en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.9006-13.1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4851
dc.identifier.volume24en_US
dc.identifier.wosWOS:000340227300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidural fibrosisen_US
dc.subjectEtanercepten_US
dc.subjectFailed back surgeryen_US
dc.subjectFibroblasten_US
dc.subjectLaminectomyen_US
dc.subjectPost-laminectomy syndromeen_US
dc.subjectRaten_US
dc.titleThe Effect of Etanercept on Spinal Epidural Fibrosis in a Postlaminectomy Rat Modelen_US
dc.typeArticleen_US

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