Adverse effects in lumbar spinal cord morphology and tissue biochemistry in Sprague Dawley male rats following exposure to a continuous 1-h a day 900-MHz electromagnetic field throughout adolescence

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dc.contributor.authorKerimoğlu, Gökçen
dc.contributor.authorAslan, Ali
dc.contributor.authorBaş, Orhan
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorOdacı, Ersan
dc.date.accessioned2020-04-30T22:39:01Z
dc.date.available2020-04-30T22:39:01Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionKerimoglu, Gokcen/0000-0002-4349-7796en_US
dc.descriptionWOS: 000390636000015en_US
dc.descriptionPubMed: 27650207en_US
dc.description.abstractCell phones, an indispensable element of daily life, are today used at almost addictive levels by adolescents. Adolescents are therefore becoming increasingly exposed to the effect of the electromagnetic field (EMF) emitted by cell phones. The purpose of this study was to investigate the effect of exposure to a 900-MHz EMF throughout adolescence on the lumbar spinal cord using histopathological, immunohistochemical and biochemical techniques. Twenty-four Sprague Dawley (28.3-43.9 g) aged 21 days were included in the study. These were divided equally into three groups control (CG), sham (SG) and electromagnetic (ELMAG). No procedure was performed on the CG rats until the end of the study. SG and ELMAG rats were kept inside an EMF cage (EMFC) for 1 h a day every day at the same time between postnatal days 22 and 60. During this time, ELMAG rats were exposed to the effect of a 900-MHz EMF, while the SG rats were kept in the EMFC without being exposed to EMF. At the end of the study, the lumbar regions of the spinal cords of all rats in all groups were extracted. Half of each extracted tissue was stored at -80 degrees C for biochemical analysis, while the other half was used for histopathological and immunohistochemical analyses. In terms of histopathology, a lumbar spinal cord with normal morphology was observed in the other groups, while morphological irregularity in gray matter, increased vacuolization and infiltration of white matter into gray matter were pronounced in the ELMAG rats. The cytoplasm of some neurons in the gray matter was shrunken and stained dark, and vacuoles were observed in the cytoplasms. The apoptotic index of glia cells and neurons were significantly higher in ELMAG compared to the other groups. Biochemical analysis revealed a significantly increased MDA value in ELMAG compared to CG, while SOD and GSH levels decreased significantly. In conclusion, our study results suggest that continuous exposure to a 900-MHz EMF for 1 h a day through all stages of adolescence can result in impairments at both morphological and biochemical levels in the lumbar region spinal cords of Sprague Dawley rats. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jchemneu.2016.09.007en_US
dc.identifier.endpage130en_US
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2016.09.007
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2567
dc.identifier.volume78en_US
dc.identifier.wosWOS:000390636000015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal Of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectromagnetic fielden_US
dc.subjectCell phoneen_US
dc.subjectLumbar spinal corden_US
dc.subjectAdolescenceen_US
dc.subjectSprague Dawley male ratsen_US
dc.titleAdverse effects in lumbar spinal cord morphology and tissue biochemistry in Sprague Dawley male rats following exposure to a continuous 1-h a day 900-MHz electromagnetic field throughout adolescenceen_US
dc.typeArticleen_US

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