Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis

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dc.contributor.authorErdem, Hakan
dc.contributor.authorÇağ, Yasemin
dc.contributor.authorEngin, Derya Öztürk
dc.contributor.authorDefres, Sylviane
dc.contributor.authorKaya, Selçuk
dc.contributor.authorLarsen, Lykke
dc.contributor.authorVahaboğlu, Haluk
dc.date.accessioned2020-04-30T23:31:41Z
dc.date.available2020-04-30T23:31:41Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionBeraud, Guillaume/0000-0002-4705-0916; Ghaydaa, Shehata/0000-0002-3631-893X; Senbayrak, Seniha/0000-0002-4983-6613; Gunst, Jesper/0000-0002-3787-0259; Kanj, Souha/0000-0001-6413-3396; Karabay, Oguz/0000-0003-0502-432X; Larsen, Lykke/0000-0002-4113-4182; Stahl, Jean Paul/0000-0002-0086-3557; johansen, isik somuncu/0000-0002-2189-9823; VAHABOGLU, Haluk/0000-0001-8217-1767en_US
dc.descriptionWOS: 000358623200015en_US
dc.descriptionPubMed: 25779579en_US
dc.description.abstractData in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.en_US
dc.identifier.doi10.1128/AAC.05016-14en_US
dc.identifier.endpage3089en_US
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3084en_US
dc.identifier.urihttps://doi.org/10.1128/AAC.05016-14
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4404
dc.identifier.volume59en_US
dc.identifier.wosWOS:000358623200015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAmer Soc Microbiologyen_US
dc.relation.ispartofAntimicrobial Agents And Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleResults of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitisen_US
dc.typeArticleen_US

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