Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Amer Soc Microbiology
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
Description
Beraud, Guillaume/0000-0002-4705-0916; Ghaydaa, Shehata/0000-0002-3631-893X; Senbayrak, Seniha/0000-0002-4983-6613; Gunst, Jesper/0000-0002-3787-0259; Kanj, Souha/0000-0001-6413-3396; Karabay, Oguz/0000-0003-0502-432X; Larsen, Lykke/0000-0002-4113-4182; Stahl, Jean Paul/0000-0002-0086-3557; johansen, isik somuncu/0000-0002-2189-9823; VAHABOGLU, Haluk/0000-0001-8217-1767
WOS: 000358623200015
PubMed: 25779579
WOS: 000358623200015
PubMed: 25779579
Keywords
Journal or Series
Antimicrobial Agents And Chemotherapy
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
59
Issue
6
