Effects of prenatal exposure to diclofenac sodium and saline on the optic nerve of 4- and 20-week-old male rats: a stereological and histological study

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dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorAktaş, Abit
dc.contributor.authorRaimondo, Stefania
dc.contributor.authorTürkmen, Aysın Pınar
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.contributor.authorOdacı, Ersan
dc.contributor.authorKaplan, Süleyman
dc.date.accessioned2020-05-01T09:12:02Z
dc.date.available2020-05-01T09:12:02Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionKaplan, Suleyman/0000-0003-1477-5002; Turkmen, Aysin/0000-0003-0330-9655; Geuna, Stefano/0000-0002-6962-831Xen_US
dc.descriptionWOS: 000329846700009en_US
dc.descriptionPubMed: 23977957en_US
dc.description.abstractWe investigated the effects of diclofenac sodium (DS) on development of the optic nerve in utero. Pregnant female rats were separated into three groups: control, saline treated and DS treated. Offspring of these animals were divided into 4-week-old and 20-week-old groups. At the end of the 4th and 20th weeks of postnatal life, the animals were sacrificed, and right optic nerves were excised and sectioned for ultrastructural and stereological analyses. We demonstrated that both DS and saline produced structural and morphometric changes in the total axon number and density of axons, but decreased the myelin sheath thickness in male optic nerves. All ultrastructural and morphometric features were well developed in 20-week-old rats. We showed that development of the optic nerve continues during the early postnatal period and that some compensation for exposure to deleterious agents in utero may occur during early postnatal life.en_US
dc.identifier.doi10.3109/10520295.2013.827741en_US
dc.identifier.endpage144en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2013.827741
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5855
dc.identifier.volume89en_US
dc.identifier.wosWOS:000329846700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiclofenac sodiumen_US
dc.subjectelectron microscopyen_US
dc.subjectmale raten_US
dc.subjectoptic nerveen_US
dc.subjectstereologyen_US
dc.titleEffects of prenatal exposure to diclofenac sodium and saline on the optic nerve of 4- and 20-week-old male rats: a stereological and histological studyen_US
dc.typeArticleen_US

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