Topical or intravenous administration of tranexamic acid accelerates wound healing

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dc.authoridkaraduman, zekeriya okan/0000-0002-6719-3666en_US
dc.authoridARİCAN, MEHMET/0000-0002-0649-2339en_US
dc.authoridsaglam, sonmez/0000-0003-2651-8003en_US
dc.authoridturhan, yalcin/0000-0002-1440-9566en_US
dc.authorscopusid57215363582en_US
dc.authorscopusid6603247087en_US
dc.authorscopusid55353048000en_US
dc.authorscopusid23768513300en_US
dc.authorscopusid57209297847en_US
dc.authorscopusid58486796000en_US
dc.authorscopusid58172080400en_US
dc.authorwosidkaraduman, zekeriya okan/AAD-6650-2020en_US
dc.authorwosidARİCAN, MEHMET/AAD-2463-2020en_US
dc.contributor.authorSaglam, Sonmez
dc.contributor.authorOrhan, Zafer
dc.contributor.authorArican, Mehmet
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorTekce, Yildiray
dc.contributor.authorYucel, Muecahid Osman
dc.date.accessioned2024-08-23T16:03:24Z
dc.date.available2024-08-23T16:03:24Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives: In this study, we aimed to investigate the morphological and histological effects of tranexamic acid (TA) on wound healing in a rat wound model.Materials and methods: A total of 24 adult mal e Wistar Albino rats were used in this study. All rats were simple randomly divided into three groups including eight rats in each group. A full-thickness skin defect was created on the back of the rats in all groups. Serum physiological (2 mL) was instilled saline drops after wound formation (control group). Wound was created and topical TA (0.12 to 0.15 mL [30 mg/kg]) was applied (local group). Intravenous TA (0.12 to 0.15 mL [30 mg/kg]) was applied intravenously before the wound was created (intravenous group). The wound diameters of the groups were photographed and measured on Days 0, 3, 7, 10, 14 and, at the end of Day 14, the rats were sacrificed and their histopathological results and wound diameters were compared.Results: Fibroblast count values of the control group were found to be significantly lower than the local group (p=0.002), and no significant difference was observed between the local and intravenous groups (p>0.05). The collagen density (%) values of the control group were found to be significantly higher than the local and intravenous groups (p=0.016 and p=0.044). Wound diameter values of the control group on Day 10 day were found to be significantly higher than the local and intravenous groups (p=0.001). In addition, the wound diameter values of the control group on Day 14 were found to be significantly higher than the local and intravenous groups (p=0.001 and p=0.0001). The wound diameter changes of the control group on Days 0-10 were found to be significantly lower than the local and intravenous groups (p=0.001). In addition, the wound diameter changes of the control group on Days 0-14 were found to be lower than those of the local and intravenous groups (p=0.001 and p=0.0001).Conclusion: The use of local or intravenous TA may have positive effects on the fibroblast count and wound contraction in a rat wound model.en_US
dc.identifier.doi10.52312/jdrs.2023.1044
dc.identifier.endpage95en_US
dc.identifier.issn2687-4792
dc.identifier.issue1en_US
dc.identifier.pmid38108169en_US
dc.identifier.scopus2-s2.0-85180385356en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage85en_US
dc.identifier.trdizinid1227229en_US
dc.identifier.urihttps://doi.org/10.52312/jdrs.2023.1044
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1227229
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13731
dc.identifier.volume35en_US
dc.identifier.wosWOS:001110703700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofJoint Diseases And Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntravenousen_US
dc.subjectlocalen_US
dc.subjectraten_US
dc.subjecttranexamic aciden_US
dc.subjectwound healingen_US
dc.subjectTotal Knee Arthroplastyen_US
dc.subjectPostoperative Blood-Lossen_US
dc.subjectPrimary Total Hipen_US
dc.subjectInjectionen_US
dc.subjectSurgeryen_US
dc.titleTopical or intravenous administration of tranexamic acid accelerates wound healingen_US
dc.typeArticleen_US

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