Cytokines in human milk and late-onset breast milk jaundice

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dc.contributor.authorApaydın, Kader
dc.contributor.authorErmiş, Bahri
dc.contributor.authorAraslı, Mehmet
dc.contributor.authorTekin, İshak
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-05-01T09:11:16Z
dc.date.available2020-05-01T09:11:16Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; tekin, ishak ozel/0000-0002-9969-4254en_US
dc.descriptionWOS: 000315093800013en_US
dc.descriptionPubMed: 22672115en_US
dc.description.abstractBackground: Maternal milk plays an important role in the development of late-onset breast milk jaundice (BMJ), possibly due to the unique characteristics of breast milk. The aim of this study was to investigate whether there is a relation between cytokine concentrations in the milk of nursing mothers and BMJ. Methods: Breast milk samples were collected from breast-feeding mothers of healthy full-term neonates, 40 with BMJ and 40 without jaundice. Milk samples were taken between the second and the fourth postpartum week. The concentrations of interleukin (IL)-1 beta, IL-6, IL-8, IL-10, and tumor necrosis factor-alpha were measured by flow cytometric bead array. Results: There were significant differences between the study groups in terms of IL-1 beta concentrations (P = 0.013). Not statistically significant but similar trends were also seen for IL-10 (P = 0.067) and tumor necrosis factor-alpha (P = 0.053) concentrations. However, no significant differences were noted in IL-6 (P = 0.174) and IL-8 (P = 0.285) concentrations. Conclusions: IL-1 beta concentration seems to be increased in milk of mothers whose infants had BMJ. Although the effect of these cytokines on BMJ is unknown, it may cause prolonged jaundice via hepatic uptake, hepatic excretion, conjugation and intestinal absorption.en_US
dc.identifier.doi10.1111/j.1442-200X.2012.03680.xen_US
dc.identifier.endpage805en_US
dc.identifier.issn1328-8067
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage801en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-200X.2012.03680.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5451
dc.identifier.volume54en_US
dc.identifier.wosWOS:000315093800013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytokinesen_US
dc.subjecthuman milken_US
dc.subjectinterleukin-1 betaen_US
dc.subjectlate-onset breast milk jaundiceen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.titleCytokines in human milk and late-onset breast milk jaundiceen_US
dc.typeArticleen_US

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