The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K-ATP channel

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dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorÖzarslan, Talat O.
dc.contributor.authorTaşkın, Eylem
dc.contributor.authorEksioğlu, Didem
dc.contributor.authorErim, Firdevs
dc.contributor.authorYaşar, Selçuk
dc.date.accessioned2020-04-30T23:34:10Z
dc.date.available2020-04-30T23:34:10Z
dc.date.issued2019
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.descriptionYASAR, SELCUK/0000-0002-9677-8823; Ozarslan, Talat Ogulcan/0000-0002-2635-7011; Yasar, Selcuk/0000-0002-7529-9751en_US
dc.descriptionWOS: 000462366900003en_US
dc.descriptionPubMed: 29457517en_US
dc.description.abstractContext: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced diabetic rats and to investigate the role of myocardial K-ATP channel in the possible anti-arrhythmic actions of the treatments. Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg, intraperitoneally (i.p.)], berberine (10 mg/kg, i.p) and glibenclamide (5 mg/kg, i.p) for 6 weeks. On the 43th day, experimental animals were subjected to 6-min ischemia and 6-min reperfusion in vivo. Results: The protein expression of Kir6.2 subunits was downregulated in the diabetic hearts. However, all drug treatments restored the protein expression of Kir6.2 subunits. Resveratrol alone and its combination with glibenclamide decreased the arrhythmia score, the arrhythmic period and the incidence of other types of arrhythmias during the reperfusion period. Conclusions: The combination of resveratrol with glibenclamide may alleviate reperfusion-induced arrhythmias via an underlying mechanism not be only associated with the restoration of the protein expression of Kir6.2 subunits but also associated with the other subunits or ion channels underlying cardiac action potential.en_US
dc.description.sponsorshipAbant Izzet Baysal University Research FundAbant Izzet Baysal University [2015.03.01.823]en_US
dc.description.sponsorshipWe would like to thank Abant Izzet Baysal University Research Fund for supporting the study [Project No.: 2015.03.01.823].en_US
dc.identifier.doi10.1080/13813455.2018.1440409en_US
dc.identifier.endpage121en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2018.1440409
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5116
dc.identifier.volume125en_US
dc.identifier.wosWOS:000462366900003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives Of Physiology And Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectarrhythmiasen_US
dc.subjectmyocardial KATP channelen_US
dc.subjectresveratrolen_US
dc.subjectglibenclamideen_US
dc.titleThe protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K-ATP channelen_US
dc.typeArticleen_US

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