Effects of isotretinoin and acitretin on neuroregeneration in experimental spinal cord injury

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dc.authoridSoylu, Hakan/0000-0002-1177-2351en_US
dc.authorscopusid57193240432en_US
dc.authorscopusid24367146700en_US
dc.authorscopusid58558899700en_US
dc.authorscopusid55982152000en_US
dc.authorwosidSoylu, Hakan/I-8911-2017en_US
dc.contributor.authorKilic, Guven
dc.contributor.authorPolat, Omer
dc.contributor.authorSensoy, Dogan
dc.contributor.authorSoylu, Hakan
dc.date.accessioned2024-08-23T16:03:25Z
dc.date.available2024-08-23T16:03:25Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: This study aimed to determine whether isotretinoin and acitretin have beneficial effects on neural tissue damage following acute spinal cord injury. Methods: Thirty-six rats were randomly divided into 6 groups: control, sham spinal cord injury, spinal cord injury with isotretinoin 15 mg/ kg for 14 days, spinal cord injury with isotretinoin 15 mg/kg for 28 days, spinal cord injury with acitretin 10 mg/kg for 14 days, and spinal cord injury with acitretin 10 mg/kg for 28 days. The damage to the spinal cord was formed by the clip compression technique. A neurological evaluation was conducted on days 1, 14, and 28. All rats were sacrificed following the treatment period, and samples of their spinal cords were collected for histopathological analysis. Results: The inclined plane angle was significantly increased on the 14th and 28th days in the isotretinoin 15 mg and acitretin 10 mg groups, compared to the spinal injury group (P=.049 and P=.009, respectively). The Drummond-Moore criterion was significantly higher in the acitretin 10 mg group than in the injury group (P=.026). Cleaved Caspase-3 expression was similar in the isotretinoin 15 mg day 28 group and the control group (P > .05), but significantly decreased in the acitretin 10 mg 14th-day and acitretin 10 mg 28th-day groups compared to spinal injury isotretinoin 15 mg 14th-day and isotretinoin 15 mg 28th-day groups (P < .05). Conclusion: This was the first study elaborating that isotretinoin and acitretin reduced neuronal apoptosis and improved functional recovery after spinal cord injury. These neuroprotective effects might open a window of opportunity for patients.en_US
dc.identifier.doi10.5152/j.aott.2023.22128
dc.identifier.endpage133en_US
dc.identifier.issn1017-995X
dc.identifier.issue4en_US
dc.identifier.pmid37670445en_US
dc.identifier.scopus2-s2.0-85169416983en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.trdizinid1244574en_US
dc.identifier.urihttps://doi.org/10.5152/j.aott.2023.22128
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1244574
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13742
dc.identifier.volume57en_US
dc.identifier.wosWOS:001104870600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Orthopaedics Traumatologyen_US
dc.relation.ispartofActa Orthopaedica Et Traumatologica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpinal cord injuryen_US
dc.subjectNeuronal damageen_US
dc.subjectNeuroprotectiveen_US
dc.subjectIsotretinoinen_US
dc.subjectAcitretinen_US
dc.subjectModelen_US
dc.titleEffects of isotretinoin and acitretin on neuroregeneration in experimental spinal cord injuryen_US
dc.typeArticleen_US

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