Pregnancy-associated plasma protein A in dialysis patients

Basit Öğe Kaydı
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorBahçebaşı, Zerrin Bicik
dc.contributor.authorDuran, Sadık
dc.contributor.authorAlçelik, Aytekin
dc.contributor.authorSoypaçacı, Zeki
dc.contributor.authorYavuz, Özlem
dc.contributor.authorÖksüz, Şükrü
dc.date.accessioned2020-04-30T23:21:27Z
dc.date.available2020-04-30T23:21:27Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604; Alcelik, Aytekin/0000-0002-3156-1076en_US
dc.descriptionWOS: 000243978400012en_US
dc.descriptionPubMed: 17243917en_US
dc.description.abstractBackground: Pregnancy-associated plasma protein A (PAPP-A) was recently described as a new marker of cardiovascular events and of inflammation in uremic patients. The aim of this study was to determine levels of PAPP-A in chronic dialysis patients and its possible relationships with renal osteodystrophy. Methods: A total of 99 adult chronic hemodialysis patients, 14 peritoneal dialysis patients and 41 control subjects were included in the study. Serum PAPP-A, intact parathormone (iPTH), calcium, phosphorus and alkaline phosphatase (ALP) were measured. The correlations between PAPP-A and iPTH, calcium, phosphorus and ALP were determined. Results: PAPP-A levels were significantly higher in peritoneal dialysis [4.5 (3.2-6.7) mU/L, median (interquartile range)], and hemodialysis patients [4.7 (3.8-6.5) mU/L] in comparison to control subjects [3.4 (3.0-5-0) mU/L] (p < 0.05). In hemodialysis patients, post-dialysis PAPP-A levels [6.2 (4.7-9.4) mU/L] were significantly higher than pre-dialysis levels [4.7 (3.8-6.5) mU/L] (p < 0.05). There was a weak but statistically significant positive correlation between serum PAPP-A and iPTH (r=0.216; p=0.041) and ALP (r=0.205; p=0.044) in the hemodialysis group. Correlation between the duration of dialysis therapy and PAPP-A levels was also significant (r=0.267; p=0.008) in the hemodialysis group. Conclusions: PAPP-A levels are elevated in acute coronary syndromes and are closely related to inflammation and oxidative stress. We conclude that PAPP-A levels are increased in dialysis patients and may reflect a greater degree of chronic inflammation than osteodystrophy in uremic patients.en_US
dc.identifier.doi10.1515/CCLM.2007.007en_US
dc.identifier.endpage66en_US
dc.identifier.issn1434-6621
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1515/CCLM.2007.007
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4196
dc.identifier.volume45en_US
dc.identifier.wosWOS:000243978400012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter & Coen_US
dc.relation.ispartofClinical Chemistry And Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthemodialysisen_US
dc.subjectinsulin-like growth factoren_US
dc.subjectinsulin-like growth factor-binding proteinen_US
dc.subjectosteodystrophyen_US
dc.subjectpregnancy-associated plasma protein Aen_US
dc.subjectrenal insufficiencyen_US
dc.titlePregnancy-associated plasma protein A in dialysis patientsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4196.pdf
Boyut:
77.64 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu