GLICLAZID INDUCED THROMBOCYTOPENIA

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dc.contributor.authorAydın, Y.
dc.contributor.authorDirektör, N.
dc.contributor.authorBerker, D.
dc.contributor.authorÖnder, E.
dc.contributor.authorGüngör, A.
dc.contributor.authorCelbek, G.
dc.date.accessioned2020-05-01T12:10:15Z
dc.date.available2020-05-01T12:10:15Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesien_US
dc.descriptionWOS: 000273144300011en_US
dc.description.abstractBackground. Drug induced thrombocytopenia is mostly related with nonsteroidal anti-inflammatory drugs (NSAID), anticonvulsants, sulfonamides, diuretics, cinchona alkaloid derivatives, penicillamine and gold salts. Oral sulfonylureas such as glibenclamide, chlorpropamide and glimepiride are known to induce thrombocytopenia. Case report. We report a 42 year old female admitted to emergency department with a complaint of hematochesia. She has been using oral gliclazide for three years. Laboratory results revealed bicytopenia: haemoglobin=8.9 g/dL (N=12.3-15.3), white blood count (WBC)=12100/mu L (N=4400-11300). platelet count=4000/mu L (N=150000-450000). All examinations to etiology of thrombocytopenia were negative including, autoimmune, infectious (viral-bacterial) and haematological diseases. Colonoscopic examination showed 50% construction of the lumen ill the first 15 cm segment of the colon by all ulcerovegetant mass. Pathological examination was reported as adenocarcinoma. Thrombocyte levels increased oil the 4(th) day after stopping gliclazid treatment. Conclusions. It is the first case of gliclazid induced thrombocytopenia in literature. So we recommended that platelet count should be regularly checked ill all patients receiving sulfontylurea drugs including gliclazid.en_US
dc.identifier.doi10.4183/aeb.2009.533en_US
dc.identifier.endpage535en_US
dc.identifier.issn1841-0987
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage533en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2009.533
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6104
dc.identifier.volume5en_US
dc.identifier.wosWOS:000273144300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsulfonylureaen_US
dc.subjectgliclaziden_US
dc.subjectthrombocytopeniaen_US
dc.titleGLICLAZID INDUCED THROMBOCYTOPENIAen_US
dc.typeArticleen_US

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