GLICLAZID INDUCED THROMBOCYTOPENIA
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Editura Acad Romane
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background. Drug induced thrombocytopenia is mostly related with nonsteroidal anti-inflammatory drugs (NSAID), anticonvulsants, sulfonamides, diuretics, cinchona alkaloid derivatives, penicillamine and gold salts. Oral sulfonylureas such as glibenclamide, chlorpropamide and glimepiride are known to induce thrombocytopenia. Case report. We report a 42 year old female admitted to emergency department with a complaint of hematochesia. She has been using oral gliclazide for three years. Laboratory results revealed bicytopenia: haemoglobin=8.9 g/dL (N=12.3-15.3), white blood count (WBC)=12100/mu L (N=4400-11300). platelet count=4000/mu L (N=150000-450000). All examinations to etiology of thrombocytopenia were negative including, autoimmune, infectious (viral-bacterial) and haematological diseases. Colonoscopic examination showed 50% construction of the lumen ill the first 15 cm segment of the colon by all ulcerovegetant mass. Pathological examination was reported as adenocarcinoma. Thrombocyte levels increased oil the 4(th) day after stopping gliclazid treatment. Conclusions. It is the first case of gliclazid induced thrombocytopenia in literature. So we recommended that platelet count should be regularly checked ill all patients receiving sulfontylurea drugs including gliclazid.
Açıklama
WOS: 000273144300011
Anahtar Kelimeler
sulfonylurea, gliclazid, thrombocytopenia
Kaynak
Acta Endocrinologica-Bucharest
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
5
Sayı
4
