Analysis of Anticancer Taxanes in Turkish Hazelnut ( Corylus avellana L.) Genotypes Using High-Performance Liquid Chromatography

Basit Öğe Kaydı
dc.contributor.authorKutluturk, Gulbahar Zehra
dc.contributor.authorDuvenci, Elif Sine
dc.contributor.authorKaragul, Bora
dc.contributor.authorYaman, Baki
dc.contributor.authorUgras, Halil Ibrahim
dc.contributor.authorSerdar, Umit
dc.contributor.authorAri, Sule
dc.date.accessioned2025-10-11T20:47:38Z
dc.date.available2025-10-11T20:47:38Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives: This study aimed to investigate the anticancer taxane profiles of edible and non-edible parts of seven Turkish hazelnut ( Corylus avellana L.) genotypes. Hazelnut is one of the healthy foods rich in nutrients and antioxidants. Its regular consumption is associated with a reduced risk of coronary heart disease and cancer. Hazelnut has been described as a plant source that produces taxanes which are widely used in many cancers. Turkiye is a homeland of hazelnut culture and has its own cultivars. Investigation of anticancer taxane profiles in different parts of Turkish hazelnut genotypes is important to show the potential and value of this plant from the perspective of the pharmaceutical and food industries. Materials and Methods: In this study, green leafy covers (GLCs) and hard shells (HSs) (non-edible parts), skinless kernels (SKs), brown-skins (BSs), and brown-skinned kernels (BSKs) (edible parts) of & Ccedil;ak & imath;ldak, Sivri, Tombul, Palaz, and Kal & imath;nkara as standard and Ham and Sivri Ya & gbreve;l & imath; as local genotypes were used. The five parts of each genotype were ground to powder and eliminated to a size of less than 80 mesh. Each part was extracted using hexane and methanol for 10-deacetylbaccatin III (10-DAB III), baccatin III (BAC III), cephalomannine, and paclitaxel analyses in three replicates. Samples and standards were analyzed by acetonitrile: water gradient method on NOVA Spher 100 Phenyl-Hexyl C18 column inhighperformance liquid chromatography reverse phase system with 228 nm ultraviolet detector and 1.0 mL/min flow rate. Microsoft Office Excel, 2016, and analysis of variance Jamovi Version 2.3 were used for statistical and data analysis, consecutively. Results: Hazelnut parts differed to a very high degree from each other in terms of the highest amount of 10- DAB III (Ham HSs, 9,15 mu g/g), BAC III (Kal & imath;nkara BSs, 7.24 mu g/g), cephalomannine (Sivri Ya & gbreve;l & imath; BSs, 6.37 mu g/g), and paclitaxel (Ham BSKs, 4.36 mu g/g) they contained. While HSs, BSKs, and BSs were rich in taxanes in all of the analyzed genotypes, SKs, and GLCs remain limited for anticancer taxanes. Conclusion: This is the first report that revealed the differences in taxane contents of Turkish hazelnuts including previously untested standard and local genotypes and their parts. Significant differences between genotype and hazelnut parts are expected to highlight the health benefits of consuming raw Turkish hazelnut with BSs and their possible use as a functional food. These results add more information to elucidate the bioactive potential of Turkish hazelnuts and their by-products and provide a promising resource for the food and pharmaceutical industry with an anticancer perspective.en_US
dc.description.sponsorshipScientific Research Projects of Idot;stanbul University [FYL-2018-31616]en_US
dc.description.sponsorshipThe authors acknowledge funding from the Scientific Research Projects of & Idot;stanbul University under Project No. FYL-2018-31616. We wish to thank Sabriye Percin OEzkorucuklu for being a scientific advisor at the beginning of the experiments.en_US
dc.identifier.doi10.4274/tjps.galenos.2023.98572
dc.identifier.endpage375en_US
dc.identifier.issn1304-530X
dc.identifier.issn2148-6247
dc.identifier.issue4en_US
dc.identifier.pmid39224934en_US
dc.identifier.scopus2-s2.0-85203694146en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage367en_US
dc.identifier.trdizinid1315849en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2023.98572
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1315849
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21498
dc.identifier.volume21en_US
dc.identifier.wosWOS:001318304500012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectCorylus avellanaen_US
dc.subjecttaxanesen_US
dc.subjectanticanceren_US
dc.subjectfunctional foodsen_US
dc.subjectby-productsen_US
dc.titleAnalysis of Anticancer Taxanes in Turkish Hazelnut ( Corylus avellana L.) Genotypes Using High-Performance Liquid Chromatographyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu