In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II

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dc.contributor.authorGençer, Nahit
dc.contributor.authorBilen, Çiğdem
dc.contributor.authorDemir, Dudu
dc.contributor.authorAtahan, Alparslan
dc.contributor.authorCeylan, Mustafa
dc.contributor.authorKüçükislamoğlu, Mustafa
dc.date.accessioned2020-04-30T23:18:27Z
dc.date.available2020-04-30T23:18:27Z
dc.date.issued2013
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionGencer, Nahit/0000-0001-7092-8857en_US
dc.descriptionWOS: 000329843900005en_US
dc.descriptionPubMed: 23330659en_US
dc.description.abstractIn this study, 4'-(phenylurenyl/thiourenyl) chalcones (14-25) were prepared from 4'-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. In vitro inhibition effects of chalcone derivatives on purified carbonic anhydrase I and carbonic anhydrase II were investigated by using the CO2 hydration method of Maren. The result showed that all the synthesized compounds inhibited the CA isoenzymes activity. 18 and 19 were found to be most active (IC50 = 25.41 m M and 23.06 mu M) for hCA I, respectively. For hCA II, 24 is the most active compound (IC50 = 14.40 mu M).en_US
dc.identifier.doi10.3109/21691401.2012.761226en_US
dc.identifier.endpage388en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage384en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2012.761226
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3328
dc.identifier.volume41en_US
dc.identifier.wosWOS:000329843900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine And Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectchalconeen_US
dc.subjectureaen_US
dc.subjectthioureaen_US
dc.subjectinhibitionen_US
dc.subjectIn vitroen_US
dc.titleIn vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and IIen_US
dc.typeArticleen_US

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