In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, 4'-(phenylurenyl/thiourenyl) chalcones (14-25) were prepared from 4'-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. In vitro inhibition effects of chalcone derivatives on purified carbonic anhydrase I and carbonic anhydrase II were investigated by using the CO2 hydration method of Maren. The result showed that all the synthesized compounds inhibited the CA isoenzymes activity. 18 and 19 were found to be most active (IC50 = 25.41 m M and 23.06 mu M) for hCA I, respectively. For hCA II, 24 is the most active compound (IC50 = 14.40 mu M).
Açıklama
Gencer, Nahit/0000-0001-7092-8857
WOS: 000329843900005
PubMed: 23330659
WOS: 000329843900005
PubMed: 23330659
Anahtar Kelimeler
carbonic anhydrase, chalcone, urea, thiourea, inhibition, In vitro
Kaynak
Artificial Cells Nanomedicine And Biotechnology
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
41
Sayı
6
