Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma

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dc.contributor.authorÖzbay, Pelin Özün
dc.contributor.authorEkinci, Tekin
dc.contributor.authorYiğit, Seyran
dc.contributor.authorYavuzcan, Ali
dc.contributor.authorUysal, Selda
dc.contributor.authorSoylu, Ferit
dc.contributor.authorÇakalağaoğlu, Fulya
dc.date.accessioned2020-04-30T23:18:39Z
dc.date.available2020-04-30T23:18:39Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000319961400001en_US
dc.descriptionPubMed: 23776335en_US
dc.description.abstractObjective: The goal of this study was to investigate the between cluster of differentiation 109 (CD109) expression and tumor diameter, invasion depth, tumor grade, presence of lymphnode metastasis, and overall survival in patients with vulvar squamous cell carcinoma, which is the most common type of vulvar cancer. Method: Twenty-six patients who underwent an operation for vulvar cancer between 1999 and 2009 in our clinic were included in this study. Immunohistochemical staining was performed on formalin-fixed and paraffin-embedded tissue. Result: Tumor diameter was not found to be significantly associated with CD109 expression, intensity of cytoplasmic staining, or combined score (P = 0.325, P = 0.169, P = 0.352, respectively). Invasion depth and combined score were also not significantly correlated with CD109 expression (P = 0.324 and P = 0.174 respectively). There was a negative correlation between invasion depth and the intensity of cytoplasmic staining (P = 0.042). There was no significant correlation between tumor stage and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.574, P = 0.389, P = 0.605, respectively). A significant positive correlation was observed between tumor grade and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.003, P = 0.018, P = 0.008, respectively). No significant difference was found between the percentages of CD109 expression in patients with positive (48%) and negative (11%) lymph nodes (P = 0.058). The percentage of CD109 expression did not significantly differ in relation to overall survival (P = 0.483). Conclusion: Comprehensive and more extensive studies are needed to examine the relationship between CD109 expression and vulvar malignant lesions.en_US
dc.identifier.doi10.2147/OTT.S41069en_US
dc.identifier.endpage627en_US
dc.identifier.issn1178-6930
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage621en_US
dc.identifier.urihttps://doi.org/10.2147/OTT.S41069
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3462
dc.identifier.volume6en_US
dc.identifier.wosWOS:000319961400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofOncotargets And Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttumor diameteren_US
dc.subjectinvasion depthen_US
dc.subjecttumor gradeen_US
dc.subjectlymph-node metastasisen_US
dc.subjectoverall survivalen_US
dc.titleInvestigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinomaen_US
dc.typeArticleen_US

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