Experimental Animal Models in Obstetrics and Gynecology
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce University Medical School
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study focuses on two major diseases affecting women's reproductive health: endometriosis and polycystic ovary syndrome (PCOS). Endometriosis is characterized as an estrogen-dependent condition, highlighting estrogen's role in understanding the disease's development and treatment strategies. Rat and mouse models are crucial for comprehending the pathophysiology of endometriosis and testing new therapeutic approaches. These models are particularly valuable in evaluating the effects of hormones and immune system modulators on endometriosis. Conversely, experimental models of PCOS emphasize the central role of hyperandrogenism in the development of this condition. Models induced by substances like dehydroepiandrosterone, testosterone propionate, and letrozole provide insights into the metabolic and endocrinological disruptions associated with PCOS. The letrozole-induced model, in particular, helps in understanding the relationship between hormonal imbalances and the onset of PCOS. Experimental models of both diseases offer critical knowledge for both basic science research and clinical applications. They provide essential data for understanding the pathophysiology of these conditions and developing new treatment strategies. This study demonstrates how findings from experimental models can improve women's reproductive health and lead to more effective treatments for these diseases. An enhanced understanding of hormonal and immune system mechanisms will guide future research and offer innovative solutions for treating these conditions. © 2024, Duzce University Medical School. All rights reserved.
Açıklama
Anahtar Kelimeler
endometriosis, Gynecological disorders, polycystic ovary syndrome, androstanolone, estrogen, letrozole, prasterone, testosterone, testosterone propionate, tumor necrosis factor, animal experiment, animal model, animal tissue, drug therapy, endometriosis, female, gynecologic disease, gynecology, human, hyperalgesia, immune system, mouse, nonhuman, obstetrics, ovary polycystic disease, pathophysiology, pelvic pain, pharmacology, pregnancy, rat, reproductive health, Review, systematic review
Kaynak
Düzce Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
26
Sayı
S1
