Antimicrobial, Antiproliferative Effects and Docking Studies of Methoxy Group Enriched Coumarin-Chalcone Hybrids

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dc.authorscopusid58101545800
dc.authorscopusid56156721800
dc.authorscopusid57216300593
dc.authorscopusid25229718700
dc.authorscopusid56078893600
dc.authorscopusid58101545900
dc.authorscopusid53876957600
dc.contributor.authorBadreddin Musatat, Ahmad
dc.contributor.authorKılıçcıoğlu, İlker
dc.contributor.authorKurman, Yener
dc.contributor.authorDülger, Görkem
dc.contributor.authorAlpay, Merve
dc.contributor.authorYağcı, Ravza
dc.contributor.authorAtahan, Alparslan
dc.date.accessioned2023-07-26T11:50:31Z
dc.date.available2023-07-26T11:50:31Z
dc.date.issued2023
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractMethoxy group enriched eight coumarin-chalcone hybrid derivatives were synthesized. Antimicrobial/ antiproliferative activities were tested against eight human pathogenic microorganisms and four cancer cell lines (AGS, HepG2, MCF-7 and PC-3), respectively. Antimicrobial results showed that most of the compounds were almost more active than used standard antibiotics. Cytotoxicity results showed that 2,3,4-trimethoxyphenyl and thiophene containing structures have promising antiproliferative effects against AGS gastric cell lines with ?5 ?g/ml IC50 values. At the same time, 2,4-dimethoxyphenyl bearing derivative exhibited the lowest IC50 values against HepG2 (?10 ?g/ml) and PC-3 (?5 ?g/ml) cell lines. Particularly, the cell viabilities of MCF-7 cell lines were remarkably inhibited by all the compounds with lower IC50 values. Therefore, molecular docking studies between hybrid ligands and quinone reductase-2 enzyme (regulates in MCF-7 cancer cells) were performed. The results demonstrated that all the derivatives can smoothly interact with interested enzyme in agreement with the experimental results. Finally, ADME parameters were studied to reveal drug-likeness potentials of the coumarin-chalcone hybrids. © 2023 Wiley-VHCA AG, Zurich, Switzerland.en_US
dc.description.sponsorship2020.07.06.1080en_US
dc.description.sponsorshipThis study was financially supported by Düzce University Scientific Research Projects Unit (Project number: 2020.07.06.1080).en_US
dc.identifier.doi10.1002/cbdv.202200973
dc.identifier.issn1612-1872
dc.identifier.issue3en_US
dc.identifier.pmid36691991en_US
dc.identifier.scopus2-s2.0-85147958982en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202200973
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12366
dc.identifier.volume20en_US
dc.identifier.wosWOS:000931925300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBadreddin Musatat, Ahmad
dc.institutionauthorKılıçcıoğlu, İlker
dc.institutionauthorKurman, Yener
dc.institutionauthorDülger, Görkem
dc.institutionauthorAlpay, Merve
dc.institutionauthorYağcı, Ravza
dc.institutionauthorAtahan, Alparslan
dc.institutionauthorDurmuş, Sefa
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistry and Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectantimicrobialen_US
dc.subjectcanceren_US
dc.subjectchalconeen_US
dc.subjectcoumarinen_US
dc.subjectmolecular dockingen_US
dc.subjectantineoplastic agenten_US
dc.subjectchalconeen_US
dc.subjectchalcone derivativeen_US
dc.subjectcoumarin derivativeen_US
dc.subjectcell proliferationen_US
dc.subjectchemical structureen_US
dc.subjectchemistryen_US
dc.subjectdrug screeningen_US
dc.subjecthumanen_US
dc.subjectMCF-7 cell lineen_US
dc.subjectmolecular dockingen_US
dc.subjectstructure activity relationen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectCell Proliferationen_US
dc.subjectChalconeen_US
dc.subjectChalconesen_US
dc.subjectCoumarinsen_US
dc.subjectDrug Screening Assays, Antitumoren_US
dc.subjectHumansen_US
dc.subjectMCF-7 Cellsen_US
dc.subjectMolecular Docking Simulationen_US
dc.subjectMolecular Structureen_US
dc.subjectStructure-Activity Relationshipen_US
dc.titleAntimicrobial, Antiproliferative Effects and Docking Studies of Methoxy Group Enriched Coumarin-Chalcone Hybridsen_US
dc.typeArticleen_US

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