Does premedication with dexmedetomidine provide perioperative hemodynamic stability in hypertensive patients?

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dc.contributor.authorSezen, Gülbin
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorŞeker, İlknur Suidiye
dc.contributor.authorKaragöz, İbrahim
dc.contributor.authorİskender, Abdülkadir
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorÖzlü, Onur
dc.date.accessioned2020-05-01T09:11:29Z
dc.date.available2020-05-01T09:11:29Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; Ersoy Karka, Ozlem/0000-0001-7309-427X; Yorulmaz, Ilknur Suidiye/0000-0002-1441-6360en_US
dc.descriptionWOS: 000346935200001en_US
dc.descriptionPubMed: 25550680en_US
dc.description.abstractBackground: Perioperative hemodynamic fluctuations are seen more often in hypertensive patients than in normotensive patients. The purpose of our study was to investigate the perioperative hemodynamic effects of dexmedetomidine and midazolam used for premedication in hypertensive patients relative to each other and in comparison to normotensive patients. Methods: One-hundred-forty female, normotensive or hypertensive patients undergoing myomectomies or hysterectomies. They were randomly enrolled into the subgroups: Group ND (normotensive-dexmedetomidine); Group HD (hypertensive-dexmedetomine); Group NM (normotensive-midazolam); Group HM (hypertensive-midazolam). Dexmedetomidine was administered at a concentration of 0.5 mu g.kg(-1), and midazolam was administered at a concentration of 0.025 mu g.kg(-1) via intravenous (IV) infusion before the induction of anaesthesia. Haemodynamic parameters were recorded at several times (T-beginning, T-preop5 min, T-preop 10 min, T-induction, T-intubation, T-intubation 5 min, T-initial surgery, T-surgery 15 min, T-surgery 30 min, T-extubation, T-extubation 5 min). Propofol amount for induction, time between induction and initial surgery, demand of antihypertensive therapy, rescue atropine were recorded. Quantitative clinical and demographic characteristics were compared using One Way ANOVA. The values were compared using One-way Analysis of Variance. Additionally periodic variations were examined by One way Repeated Measures Analysis of Variance for groups separately. Results: SBP was significantly different between normotensive and hypertensive groups at the following time points: T-preop 5 min, T-preop 10 min, T-induction, T-intubation, T-intubation 5 min and T-initial surgery. MBP was significantly different in the hypertensive groups at T-induction, T-intubation, T-intubation 5 min, T-initial surgery, T-surgery 15 min, T-surgery 30 min, T-extubation and T-extubation 5 min. The perioperative requirements for antihypertensive drugs were significantly higher in Group HM. Conclusion: In the hypertensive patients, dexmedetomidine premedication provides better hemodynamic stability compared with midazolam, and because it decreases the antihypertensive requirements, its use might be beneficial.en_US
dc.description.sponsorshipDuzce University's Projects Support Fund for Scientific ResearchDuzce Universityen_US
dc.description.sponsorshipThis study was financed by Duzce University's Projects Support Fund for Scientific Research.en_US
dc.identifier.doi10.1186/1471-2253-14-113en_US
dc.identifier.issn1471-2253
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/1471-2253-14-113
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5622
dc.identifier.volume14en_US
dc.identifier.wosWOS:000346935200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofBmc Anesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectMidazolamen_US
dc.subjectPremedicationen_US
dc.subjectHypertensionen_US
dc.titleDoes premedication with dexmedetomidine provide perioperative hemodynamic stability in hypertensive patients?en_US
dc.typeArticleen_US

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